@article {46415,
	title = {C-H functionalization of indoles by 3d transition-metal catalysis},
	journal = {Asian Journal of Organic Chemistry},
	year = {2019},
	month = {DEC},
	type = {Review; Early Access},
	abstract = {<p>Over the past decade, the use of 3d transition metal for the regioselective C-H bond functionalization of indoles has significantly increased. Particularly, advances in manganese, iron, cobalt, nickel and copper catalysis have demonstrated the selective C(2)-H and C(3)-H arylation, alkenylation, alkynylation and alkylation to a greater extent. Similarly, the C-O and C-N bond-forming reactions are manifested via direct C-H bond activation by these earth-abundant metals. The emergence of 3d metals in selective functionalization of the biologically relevant indoles and related heteroarenes would make this protocol more attractive for practical applications. Herein, we provide a brief overview of 3d transition metal-catalyzed (mostly Mn, Fe, Co, Ni and Cu) C-H functionalization of indoles and related heteroarenes.</p>
},
	keywords = {3d transition metal, C-H functionalization, Indole, indoline},
	issn = {2193-5807},
	doi = {10.1002/ajoc.201900554},
	author = {Jagtap, Rahul A. and Punji, Benudhar}
}
@article {46884,
	title = {Copper-catalyzed direct arylation of indoles and related (hetero)arenes: a ligandless and solvent-free approach},
	journal = {Advanced Synthesis \& Catalysis},
	volume = {362},
	year = {2020},
	month = {JUN },
	pages = {2534-2540},
	type = {Article},
	abstract = {<p>A ligandless and solvent-free copper-catalyzed method for the regioselective C-H bond arylation of indoles and related heteroarenes is reported. The use of CuCl efficiently catalyzes the direct coupling of diverse heteroarenes with aryl iodides via chelation-assistance. This reaction could tolerate sensitive and structurally diverse functionalities, including halides, ethers, thioethers, amines, indolyl, pyrrolyl and carbazolyl groups. The directing group, 2-pyridinyl can be smoothly removed to generate C-2 arylated free-NH indoles, and the arylated indoles can further be functionalized into Tryptamine derivatives. Preliminary mechanistic study revealed a radical pathway for the arylation reaction.</p>
},
	keywords = {Arylation, C-H activation, Chelation-assistance, Copper, Indole, Solvent-free},
	issn = {1615-4150},
	doi = {10.1002/adsc.202000312, Early Access Date = APR 2020},
	author = {Pandey, Dilip K. and Shabade, Anand B. and Punji, Benudhar}
}
