@article {49322,
	title = {Manganese-catalyzed chemoselective direct hydrogenation of α,β-epoxy ketones and α-ketoamides at room temperature},
	journal = {Advanced Synthesis \& Catalysis},
	volume = {366},
	year = {2024},
	month = {AUG},
	pages = {3338-3345},
	type = {Article},
	abstract = {<p>
	Chemoselective hydrogenation of alpha,beta-epoxy ketones and alpha-ketoamides is achieved at room temperature (25 degrees C) using 2.0 bar H-2 and a pincer-ligated Mn(I) catalyst that provides synthetically valuable alpha-hydroxy epoxides and alpha-hydroxy amides. This protocol applies to a wide range of alkyl- and aryl-substituted alpha,beta-epoxy ketones, including terpenes (alpha-ionone, nootkatone, and R-carvone)- and steroids (testosterone and progesterone)-derived epoxy ketones, and tolerates H-2 sensitive functionalities, such as halides, acetyl, nitrile, nitro, epoxide, alkenyl and alkynyl groups. Additionally, alpha-ketoamides bearing reducible functional groups, including acetyl and diazo benzene, were untouched under this protocol and selectively converted to alpha-hydroxy amides. A preliminary mechanistic study highlighted the metal-ligand cooperative H-2 activation process.</p>
},
	keywords = {alpha, beta-epoxy ketones, chemoselectivity, direct hydrogenation, manganese, Metal-ligand cooperation},
	issn = {1615-4150},
	doi = {10.1002/adsc.202400267},
	author = {Shabade, Anand B. and Singh, Rahul K. and Gonnade, Rajesh G. and Punji, Benudhar}
}
@article {49023,
	title = {Nickel-catalyzed chemodivergent coupling of alcohols: efficient routes to access α,α-disubstituted ketones and α-substituted chalcones},
	journal = {Chemistry- a european journal},
	volume = {30},
	year = {2024},
	month = {MAR},
	type = {Article},
	abstract = {<p>
	Chemodivergent (de)hydrogenative coupling of primary and secondary alcohols is achieved utilizing an inexpensive nickel catalyst, (6-OH-bpy)NiCl2. This protocol demonstrates the synthesis of branched carbonyl compounds, alpha,alpha-disubstituted ketones, and alpha-substituted chalcones via borrowing hydrogen strategy and acceptorless dehydrogenative coupling, respectively. A wide range of aryl-based secondary alcohols are coupled with various primary alcohols in this tandem dehydrogenation/hydrogenation reaction. The nickel catalyst, along with KOtBu or K2CO3, governed the selectivity for the formation of branched saturated ketones or chalcones. A preliminary mechanistic investigation confirms the reversible dehydrogenation of alcohols to carbonyls via metal-ligand cooperation (MLC) and the involvement of radical intermediates during the reaction. The chemodivergent nickel-catalyzed approach provides alpha,alpha-disubstituted ketones from aryl-substituted secondary alcohols and benzyl alcohols via the borrowing hydrogen (BH) strategy in the presence of KOtBu, whereas exclusively alpha-substituted chalcones were accomplished in the presence of mild base K2CO3 through an acceptorless dehydrogenative coupling (ADC) strategy. image</p>
},
	keywords = {Alcohols, dehydrogenative coupling, Metal-ligand cooperation, Nickel, substituted carbonyl compounds},
	issn = {0947-6539},
	doi = {10.1002/chem.202304082},
	author = {Bansal, Sadhna and Punji, Benudhar}
}
