@article {46415, title = {C-H functionalization of indoles by 3d transition-metal catalysis}, journal = {Asian Journal of Organic Chemistry}, year = {2019}, month = {DEC}, type = {Review; Early Access}, abstract = {

Over the past decade, the use of 3d transition metal for the regioselective C-H bond functionalization of indoles has significantly increased. Particularly, advances in manganese, iron, cobalt, nickel and copper catalysis have demonstrated the selective C(2)-H and C(3)-H arylation, alkenylation, alkynylation and alkylation to a greater extent. Similarly, the C-O and C-N bond-forming reactions are manifested via direct C-H bond activation by these earth-abundant metals. The emergence of 3d metals in selective functionalization of the biologically relevant indoles and related heteroarenes would make this protocol more attractive for practical applications. Herein, we provide a brief overview of 3d transition metal-catalyzed (mostly Mn, Fe, Co, Ni and Cu) C-H functionalization of indoles and related heteroarenes.

}, keywords = {3d transition metal, C-H functionalization, Indole, indoline}, issn = {2193-5807}, doi = {10.1002/ajoc.201900554}, author = {Jagtap, Rahul A. and Punji, Benudhar} } @article {47290, title = {3 d transition metal-catalyzed hydrogenation of nitriles and alkynes}, journal = {Chemistry-An Asian Journal}, volume = {15}, year = {2020}, month = {MAR}, pages = {690-708}, type = {Review}, abstract = {

Selective hydrogenation of nitriles and alkynes is crucial considering the vast applications of reduced products in industries and in the synthesis of bioactive compounds. Particularly, the late 3d transition metal catalysts (manganese, iron, cobalt, nickel and copper) have shown promising activity for the hydrogenation of nitriles to primary amines, secondary amines and imines. Similarly, semihydrogenation of alkynes to E- and Z-alkenes by 3d metals is adequately successful both via the transfer hydrogenation and by using molecular hydrogen. The emergence of 3d transition metals in the selective synthesis of industrially relevant amines, imines and alkenes makes this protocol more attractive. Herein, we provide a concise overview on the late 3d transition metal-catalyzed hydrogenation of nitriles to amines and imines as well as semihydrogenation of alkynes to alkenes.

}, keywords = {3d transition metal, Alkynes, Hydrogenation, nitriles, Semihydrogenation}, issn = {1861-4728}, doi = {10.1002/asia.201901762, Early Access Date = FEB 2020}, author = {Sharma, Dipesh M. and Punji, Benudhar} } @article {47042, title = {Advances in C(sp(2))-H/C(sp(2))-H oxidative coupling of (Hetero)arenes using 3d transition metal catalysts}, journal = {Advanced Synthesis \& Catalysis}, volume = {363}, year = {2021}, month = {APR}, pages = {1998-2022}, type = {Review}, abstract = {

C-H/C-H oxidative coupling has emerged as a straightforward and powerful technique for the construction of (hetero)biaryls, with substantial application to drug discovery, agrochemicals, biology, and material sciences. Mainly aryl-aryl, aryl-heteroaryl, and heteroaryl-heteroaryl couplings via double C(sp(2))-H activation using 4d or 5d noble transition metal catalysts have been extensively studied. Considering the earth-abundant and inexpensive nature of 3d transition metals, the sustainable development of C(sp(2))-H/C(sp(2))-H oxidative coupling employing such metal catalysts has gained significant attention. In this review, we present a comprehensive overview of C(sp(2))-H/C(sp(2))-H oxidative coupling of (hetero)arenes catalyzed by 3d transition metals.

}, keywords = {(hetero)biaryls, 3d transition metal, Biaryls, C-H activation, cross-dehydrogenative coupling}, issn = {1615-4150}, doi = {10.1002/adsc.202001498, Early Access Date = MAR 2021}, author = {Bansal, Sadhna and Shabade, Anand B. and Punji, Benudhar} }