@article {49551,
	title = {Hybrid pincer (PNN)Ni(II) complex catalyzed selective C-H alkylation of pyridones using unactivated alkyl chlorides},
	journal = {ACS Catalysis},
	volume = {15},
	year = {2025},
	month = {FEB},
	pages = {2987-2999},
	type = {Article},
	abstract = {<p>
	The use of readily accessible unactivated alkyl chlorides in the alkylation reaction to install valuable alkyl and methyl motifs into privileged heterocycles is an underdeveloped area. Herein, we report the regioselective C-H alkylation of diverse pyridones employing challenging unactivated alkyl chlorides as coupling partners, enabled by a strategically developed quinolinyl-based pincer (Ph2PNNQ)Ni(II) complex. The air-stable nickel catalyst is highly effective for the selective alkylation of functionalized 2-pyridones with both primary and secondary alkyl chlorides as well as for the unexpected C6 methylation, furnishing a wide range of 6-alkyl-2-pyridone scaffolds (78 examples). Remarkably, the alkyls bearing biologically and pharmacologically significant motifs, such as pterostilbene, nonyl phenol, sesamol, estrone, vitamin E, stigmasterol, cholesterol, and diosgenin, were compatible under this catalytic approach. The insights into the mechanism suggest that the alkylation reaction follows a Ni(II)/Ni(III)/Ni(IV) pathway involving the crucial two-step, one-electron oxidative addition of alkyl chloride. Several control studies, kinetics, and EPR analyses were performed to understand the detailed reaction pathway, further supported by density functional theory calculations.</p>
},
	keywords = {alkyl chlorides, C-H/C-Cl activation, hybrid pincer ligand, Mechanism, Nickel, pyridones},
	issn = {2155-5435},
	doi = {10.1021/acscatal.4c07173},
	author = {Verma, Suryadev K. and Samal, Pragnya Paramita and Pradhan, Chandini and Pandey, Dilip K. and Krishnamurty, Sailaja and Punji, Benudhar}
}
@article {49698,
	title = {Regioselective difluoroalkylation of 2-pyridones with fluoroalkyl bromides enabled by a nickel(II) catalyst},
	journal = {Chemistry-An Asian Journal},
	volume = {20},
	year = {2025},
	month = {MAY},
	type = {Article},
	abstract = {<p>
	Regioselective C-H difluoroalkylation of diverse 2-pyridones with ethyl bromodifluoroacetates and bromodifluoroacetamides is accomplished by using a (dppf)NiCl2 catalyst under mild conditions. This efficient protocol could deliver a variety of C-3 difluoroalkylated pyridones with the tolerance of a range of highly susceptible functionalities, such as -Cl, -Br, -I, -COMe, -CN, -NMe2 and -NO2, including heteroarenes like pyridinyl, furanyl, thiophenyl and carbazolyl moieties. A preliminary mechanistic study suggests the radical pathway for the reaction involving fluoroalkyl radical intermediate.</p>
},
	keywords = {2-pyridones, Difluoroalkylation, Nickel, radical intermediate, Regioselectivity},
	issn = {1861-4728},
	doi = {10.1002/asia.202401870},
	author = {Pradhan, Chandini and Khandelwal, Disha and Punji, Benudhar}
}
