@article {49279,
	title = {Uncovering diverse reactivity of NHCs withdiazoalkane: C-H activation, C=C bond formation,and access to N-heterocyclic methylenehydrazine},
	journal = {Chemical Science},
	volume = {15},
	year = {2024},
	month = {NOV},
	pages = {18387-18394},
	type = {Article},
	abstract = {<p>
	N-heterocyclic carbenes (NHCs) have attracted significant attention due to their strong sigma-donating capabilities, as well as their transition-metal-like reactivity towards small molecules. However, their interaction with diazoalkanes remains understudied. In this manuscript, we explore the reactivity of a series of stable carbenes, encompassing a wide range of electronic properties, with Me3SiCHN2. 5-SIPr activates the C-H bond of Me3SiCHN2, resulting in the formation of a novel diazo derivative (1), while carbenes such as 5-IPr, 6-SIPr, and diamido carbene yield N-heterocyclic methylenehydrazine derivatives (3, 4, and 8). The reaction of Me3SiCHN2 with 5-ItBu unexpectedly leads to the formation of a triazole ring linked with the imidazole moiety via a CC double bond (6) alongside the azine product (7). Substituting the diazoalkane with diazoester consistently yields azine derivatives (9-12 and 14). Only in the case of 5-ItBu, an imidazolium salt with tetrazenide anion (13) was obtained as a side product. The reaction of 4 with HCl resulted in the desilylprotonation to form a salt, 5a, which undergoes deprotonation upon using bases such as Et3N and KHMDS to form N-heterocyclic methylene hydrazine, 5. Theoretical calculations have been conducted to elucidate the diverse mechanisms underlying product formation.</p>
},
	issn = {2041-6520},
	doi = {10.1039/d4sc05740f},
	author = {Balayan, Kajal and Sharma, Himanshu and Vanka, Kumar and Gonnade, Rajesh G. and Sen, Sakya S.}
}
@article {49381,
	title = {Unravelling the prebiotic origins of the simplest α-ketoacids in cometary ices: a computational investigation},
	journal = {CHEMICAL COMMUNICATIONS},
	volume = {60},
	year = {2024},
	month = {OCT },
	pages = {11283-11286},
	type = {Journal Article},
	keywords = {GLYOXYLATE, Hydrocarbons, Metabolism, Precursors},
	issn = {1359-7345},
	doi = {10.1039/d4cc03074e},
	author = {Dash, Soumya Ranjan and Pandya, Rinu and Singh, Geetika and Sharma, Himanshu and Das, Tamal and Haldar, Hritwik and Hotha, Srinivas and Vanka, Kumar}
}
