@article {47804,
	title = {Green antibacterial molecules: sophorolipids with varying fatty acid chain},
	journal = {Trends in Biomaterials and Artificial Organs},
	volume = {35},
	year = {2021},
	month = {NOV},
	pages = {431+},
	type = {Article},
	abstract = {Antibiotic resistance is a rising problem of over the last decade making it difficult to treat infections caused by various pathogenic bacteria. To tackle this problem, newer antimicrobial strategies are being explored. Sophorolipids (SLs) are a class of biomolecules produced by a non-pathogenic yeast Starmarella bombicola (S. bombicold) with surfactant as well as potent broad spectrum antibacterial activity. In this work, we have successfully synthesized sophorolipids using different fatty acids with increasing chain length of hydrophobic tail; Lauric acid (C12)-LASL, Myristic acid (C14)-MASL, Palmitic acid (C16)-PASL and Stearic acid (C18)-SASL. We have used various techniques like FTIR, HRMS to characterize the synthesized SL. Further, we have measured properties like the critical micellar concentration for these biosurfactants and the SL{\textquoteright}s showed CMC less than or equal to 100 mg/L indicating excellent surface-active property. We have studied the antibacterial activity against gram-negative and gram-positive bacteria. Interestingly, the antibacterial activity was found to be more potent as the chain length of the fatty acid in the SL decreased. This trend was found to be reverse for toxicity towards mammalian cells. The shorter chain fatty acid SL{\textquoteright}s were found to be less cytotoxic. These results indicate that the sophorolipid candidates with shorter chain lengths would be beneficial for various biomedical applications such as tissue engineering, regenerative medicine and wound healing. Keywords: sophorolipid, biosurfactant, short chain fatty acid, antibacterial},
	keywords = {Antibacterial agents, Cells (Biology), Infection, Microbial drug resistance, Saturated fatty acids, Surface active agents},
	isbn = {09711198},
	url = {https://link.gale.com/apps/doc/A684660702/AONE?u=anon~d0cd1b4e\&sid=googleScholar\&xid=1a6d61d9},
	author = {Hirlekar, Swarali and Abhyankar, Isha and Kane, Kartiki and Trimukhe, Kalpana and Prabhune, Asmita and Nisal, Anuya}
}
