@article { ISI:000248356100011,
	title = {Enantioselective synthesis of (S)-timolol via kinetic resolution of terminal epoxides and dihydroxylation of allylamines},
	journal = {Tetrahedron},
	volume = {63},
	number = {14},
	year = {2007},
	month = {APR},
	pages = {3026-3030},
	publisher = {PERGAMON-ELSEVIER SCIENCE LTD},
	type = {Article},
	address = {THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND},
	abstract = {<p>An efficient enantioselective synthesis of (S)-timolol has been described using chiral Co-salen-catalyzed kinetic resolution of less expensive (+/-)-epichlorohydrin with 3-hydroxy-4-(N-morpholino)-1,2,5-thiadiazole in good overall yield (55\%) and excellent enantioselectivity (98\%). Synthesis of (S)-timolol has also been achieved using hydrolytic kinetic resolution as well as asymmetric dihydroxylation routes in 90\% ee and 56\% ee, respectively. (c) 2007 Elsevier Ltd. All rights reserved.</p>},
	keywords = {asymmetric reactions, diols, epoxides, Kinetic resolution, oxazolidinone},
	issn = {0040-4020},
	doi = {10.1016/j.tet.2007.01.057},
	author = {Narina, Srinivasarao V. and Sudalai, Arumugam}
}
@article { ISI:000364968800017,
	title = {First enantioselective synthesis of surinamensinol B and a non-natural polysphorin analogue by a two-stereocentered hydrolytic kinetic resolution},
	journal = {European Journal of Organic Chemistry},
	volume = {33},
	number = {33},
	year = {2015},
	month = {NOV},
	pages = {7344-7351},
	publisher = {WILEY-V C H VERLAG GMBH},
	address = {POSTFACH 101161, 69451 WEINHEIM, GERMANY},
	abstract = {<p>An efficient and economical approach to the synthesis of antitumor and anti-inflammatory surinamensinol B (1) and antimalarial polysphorin analogue 2 has been achieved with high enantiomeric purity (96\% ee) by starting from commercially available 3,4,5-trimethoxybenzaldehyde. The key steps of the strategy include a Co-catalyzed two-stereocentered hydrolytic kinetic resolution (HKR) of racemic 2[( methoxymethoxy)(3,4,5-trimethoxyphenyl)methyl] oxirane (13) as the chiral inducing step followed by a Mitsunobu reaction. Chiral epoxide 14 and chiral diol 15 were utilized in the syntheses of both compounds.</p>},
	keywords = {Biological activity, Enantioselectivity, Kinetic resolution, Natural products, Total synthesis},
	issn = {1434-193X},
	doi = {10.1002/ejoc.201501009},
	author = {Lalwani, Komal G. and Sudalai, Arumugam}
}
