@article {47676,
	title = {Ni-catalyzed highly enantioselective synthesis of sulfur protected P-stereogenic supramolecular phosphine},
	journal = {Journal of Chemical Sciences},
	volume = {133},
	year = {2021},
	month = {DEC},
	pages = {119},
	type = {Article},
	abstract = {As phosphines readily invert, the synthesis of P-chiral phosphines is a challenging task and has been rarely investigated. We report the synthesis of a nickel complex [Ni-((S,S)Me-FerroLANE)(phenyl)(I)] (Ni-Cat.1) and its performance in a P-C coupling reaction to generate P-chiral phosphine. The Ni-Cat.1 was synthesized by mixing ligand (S,S) Me-FerroLANE with the metal precursor [(diphenylphosphanyl)nickel(phenyl)(I)] in good yield. Ni-Cat.1 was characterized using different spectroscopic and analytical techniques. Treatment of racemic methyl(phenyl)phosphine (1) with 1-(3-iodophenyl)urea (2) produced the corresponding P-chiral supramolecular phosphine (3). Optimization of reaction parameters produced sulfur protected phosphine N-(3-(methyl(phenyl)phosphorothioyl)phenyl)formamide (3{\textquoteright}) with excellent enantiomeric excess (99\% ee) and moderate conversion (51\%).},
	keywords = {Asymmetric synthesis, Nickel catalyst, P-C coupling, P-Stereogenic phosphine, supramolecular ligands},
	issn = {0974-3626},
	doi = {10.1007/s12039-021-01978-3},
	author = {Koshti(S), Vijay S. and Chandanshive, Amol C. and Mote, Nilesh R. and Chikkali, Samir H.}
}
