@article { ISI:000346161500008,
	title = {Protecting-group-free diastereoselective total synthesis of (+/-)-6-epi-cleistenolide and chemoenzymatic synthesis of (-)-6-epi-cleistenolide},
	journal = {European Journal of Organic Chemistry},
	number = {36},
	year = {2014},
	month = {DEC},
	pages = {8049-8054},
	publisher = {WILEY-V C H VERLAG GMBH},
	address = {BOSCHSTRASSE 12, D-69469 WEINHEIM, GERMANY},
	abstract = {<p>A short, efficient, practical, and protecting-group-free diastereoselective total synthesis of (+/-)-6-epi-cleistenolide (1) has been achieved in five steps in 60\% overall yield. The use of a chemoenzymatic approach also gave (-)-6-epi-cleistenolide (1) (\&gt;99.9\% ee). The Achmatowicz reaction, chemoselective oxidation of a hemiacetal, diastereoselective 1,3-anti reduction of alpha-hydroxy ketone, and enzymatic resolution of a 1,3-diol are the key features of this linear total synthesis. The synthetic strategy demonstrated in this paper could be extended for an asymmetric total synthesis of (-)-cleistenolide (1) and related biologically active natural products.</p>},
	keywords = {Asymmetric synthesis, diastereoselectivity, Enzyme catalysis, Lipases, Oxygen heterocycles, Total synthesis},
	issn = {1434-193X},
	doi = {10.1002/ejoc.201403123},
	author = {Mahajan, Pankaj S. and Gonnade, Rajesh G. and Mhaske, Santosh B.}
}
