@article {47399,
	title = {gamma-Al2O3/triflic acid as cooperative catalysts for the tandem Michael addition/carbocyclization: an easy access to 2-substituted pyrrolo[2,1-a]isoquinolines and 3-substituted pyrrolidine-2,5-diones},
	journal = {Journal of Heterocyclic Chemistry},
	volume = {58},
	year = {2021},
	month = {JUL},
	pages = {1415-1428},
	type = {Article},
	abstract = {<p>A tandem Michael addition/carbocyclization of 3,4-dimethoxyphenethyl maleimide with carbon and sulfur nucleophiles is accomplished via a relay catalysis using gamma-Al2O3/TfOH binary system. The X-ray Photoelectron Spectroscopy (XPS) analysis of binary system indicates the presence of AlF3, AlO(OH) species(.) This approach provides an easy access to 2-aryl or 2-thio aryl pyrrolo[2,1-a]isoquinolines in good yields in a tandem fashion. With suitable ratio of gamma-Al2O3/TfOH binary system, the Michael addition of N/C/S nucleophiles to N-benzyl maleimide is also achieved. A key to the success of these reactions would be the generation of AlF3, AlO(OH) species from gamma-Al2O3 and TfOH, which might have delineated the disadvantageous background reactions usually displayed by a strong Bronsted acid such as TfOH.</p>},
	keywords = {1-a]isoquinolines, 3-substituted pyrrolidine-2, 5-diones, carbocyclization, gamma-Al2O3/TfOH binary system, Michael addition, pyrrolo[2},
	issn = {0022-152X},
	doi = {10.1002/jhet.4266, Early Access Date = APR 2021},
	author = {Rao, Ramana Sreenivasa and Sahani, Anita and Ali, Sheikh Haider and Pradhan, Sumanta and Ramanathan, Chinnasamy Ramaraj}
}
