@article {47050,
	title = {Protriptyline improves spatial memory and reduces oxidative damage by regulating NF kappa B-BDNF/CREB signaling axis in streptozotocin-induced rat model of Alzheimer{\textquoteright}s disease},
	journal = {Brain Research},
	volume = {1754},
	year = {2021},
	month = {MAR },
	pages = {147261},
	type = {Article},
	abstract = {<p>Antidepressants are well known to exert their role via upregulation of brain derived neurotrophic factor (BDNF). BDNF has been reported to exerts its neuroprotective effect in rodent and primate models as well as in patients of Alzheimer{\textquoteright}s disease (AD). The aim of our study was to evaluate the effect of protriptyline (PRT), a tricyclic antidepressant, in streptozotocin (STZ)- induced rat model of AD. Total 10 mu l of STZ was injected into each ventricle (1 mg/kg). PRT (10 mg/kg, i.p.) treatment was started 3-day post STZ administration and continued till 21 days. We found that STZ treatment significantly increased pTau, A beta 42 and BACE-1 expression, oxidative stress and neurodegeneration in hippocampus and cortex of adult rats. STZ induced impairment in spatial learning and retention memory was associated with increased WO and reduced CREB and BDNF expression in cortex and hippocampus. Interestingly, PRT treatment significantly reduced pTau, A beta 42 and BACE-1 levels, neurodegeneration, oxidative stress and glial activation, contributing to the improved spatial learning and retention memory in STZ treated rats. Moreover, PRT treatment significantly improved p-ERK/ERK ratio and enhanced BDNF and CREB levels by reducing NFXB and GFAP expression in STZ treated rats. Our data suggest that impaired NFXB and CREB signaling potentially contribute in AD pathogenesis by elevating oxidative stress and neuroinflammation mediated neurodegeneration. Our study has established protriptyline as a multi target molecule in pre-clinical model of AD and further investigations on PRT like molecules could pave way for further development of effective new treatments in neurodegenerative disorders.</p>
},
	keywords = {Alzheimer{\textquoteright}s disease, antidepressant, BDNF, Memory, Oxidative stress, Protriptyline},
	issn = {0006-8993},
	doi = {10.1016/j.brainres.2020.147261},
	author = {Tiwari, Virendra and Mishra, Akanksha and Singh, Sonu and Mishra, Sandeep Kumar and Sahu, Kiran Kumari and Parul and Kulkarni, Mahesh J. and Shukla, Rakesh and Shukla, Shubha}
}
@article {50054,
	title = {Enhanced electrochemical performance of flexible polymer supercapacitors through optimization of organic acid-doping, carbon nanomaterials, and fabrication techniques},
	journal = {Journal of Power Sources},
	volume = {666},
	year = {2026},
	month = {FEB},
	pages = {239042},
	type = {Article},
	abstract = {<p>
	The proliferation of portable and wearable electronics necessitates flexible, high-performance energy storage devices. Flexible supercapacitors are poised to meet these demands due to their high power density, flexibility, and durability but scalable fabrication remains challenging due to costly and complex manufacturing methods. This study addresses this issue by implementing scalable, cost-effective spray coating and screen printing techniques to fabricate flexible micro-interdigitated supercapacitors (FMIS) based on Polyaniline (PANI) composites with carbon nanomaterials, using organic acids as crosslinking agents synthesized via hydrogel strategy. The formation of PANI emeraldine salt was verified through X-ray photoelectron spectroscopy, indicating key amine and imine functionalities, while scanning electron microscopy revealed surface morphologies with enhanced active surface areas beneficial for charge storage. Advanced 3D tomography maps porosity distribution and surface area per unit volume, correlating with electroactive areas calculated from the Randles-Sevcik equation. Electrochemical testing via cyclic voltammetry demonstrates an impressive areal capacitance of 173.2 +/- 9.6 mF cm-2 at 10 mV s-1 with Dunn{\textquoteright}s method distinguishing capacitive from diffusive contributions. Furthermore, EIS measurements highlight lower solution resistance in screen-printed devices, emphasizing the advantages of optimized electrode morphology for efficient charge transport. This study establishes a scalable approach for high-performance flexible supercapacitors, paving the way for next-generation energy storage solutions.</p>
},
	keywords = {Carbon nanomaterials, Coating techniques, Flexible Supercapacitors, PANI composites, X-ray micro-tomography},
	issn = {0378-7753},
	doi = {10.1016/j.jpowsour.2025.239042},
	author = {Parul and Lakshmi, Racherla Bhagya and Utturkar, Vivek and Natu, Varun and Aramanda, Shanmukha Kiran and Ramamurthy, Praveen C. and Kaka, Fiyanshu}
}
