@article {49335,
	title = {Thermally stable P-chiral supramolecular phosphines, their self-assembly and implication in Rh-catalyzed asymmetric hydrogenation},
	journal = {Chemistry-A European Journal},
	volume = {30},
	year = {2024},
	month = {AUG },
	type = {Article},
	abstract = {<p>
	P-chiral supramolecular phosphine ligands are crucial for asymmetric transformations, but their synthesis is tedious. We report a one-step synthesis of thermally stable P-chiral supramolecular phosphines and their performance in the asymmetric hydrogenation of functionalized alkenes. A rational designing and synthesis of (R, R)-QuinoxP* ligated palladium complex (Pd-2) in excellent yield is reported. This Pd-2 catalyzed a direct P-C coupling of 2,3-dihydro-1-H-phosphindole (A1)/1,2,3,4-tetrahydrophosphindoline (A2) with 1-(3-iodophenyl)urea (B1)/2-iodo /6-hydroxy pyridine (B2) and,produced corresponding ligands L1-L3. The P-C coupling between A1 and B2 produced 6-(2,3-dihydro-1H-phosphindol-1-yl)pyridine-2(1H)-one (L2) with an excellent enantiomeric excess of up to 99 \%. L2 was found to be remarkably stable even at 150 degrees C and did not oxidize/hydrolyze for at least 24 hours in open air. Such thermal stability and an impediment to oxidation are unprecedented. L2 self-assembled and produced L2-C1 (Pt), L2-C2(Pd), and L2-C3(Rh) assemblies. The utility of the self-assembled P-chiral ligand was demonstrated in the Rh-catalyzed asymmetric hydrogenation (AH) of functionalized olefins. The L2-C3 catalyzed AH of functionalized alkenes and delivered chiral products with excellent enantioselectivity of \&gt;99 \%. A small library of 16 substrates was subjected to AH using L2-C3 to produce chiral compounds with excellent conversion and ee.</p>
},
	keywords = {asymmetric hydrogenation, Asymmetric phosphination, P-chiral phosphine, Self-assembly, Supramolecular phosphine},
	issn = {0947-6539},
	doi = {10.1002/chem.202401077},
	author = {Chandanshive, Amol C. and Gonnade, Rajesh G. and Chikkali, Samir H.}
}
@article {49782,
	title = {Direct synthesis of phosphine-phosphite ligand and its implication in asymmetric hydrogenation of functionalized olefins},
	journal = {Chemistryselect},
	volume = {11},
	year = {2026},
	month = {FEB },
	pages = {e07548},
	type = {Article},
	abstract = {<p>
	Phosphine-phosphite (P-OP) ligands constitute a privileged class of chiral ligands in asymmetric catalysis owing to their modular structures and tunable steric and electronic properties. Herein, we report a direct, one-pot, synthesis of a new flexible P-OP ligand (L) derived from BINOL-PCl and its in situ complexation with rhodium (Rh) for catalytic evaluation. The resulting Rh/L system efficiently hydrogenates a diverse library of 19 functionalized olefins under mild conditions, delivering moderate to excellent enantioselectivities, with ee values reaching up to 99\%. Several of the hydrogenated products correspond to valuable chiral building blocks relevant to pharmaceutical synthesis, underscoring the practical utility of flexible P-OP ligand architectures in asymmetric hydrogenation.</p>
},
	keywords = {asymmetric hydrogenation, functionalized alkene, ligand design, metal catalyzed, phosphine-phosphite},
	issn = {2365-6549},
	doi = {10.1002/slct.202507548},
	author = {Chandanshive, Amol C. and Khopade, Kishor V. and Chikkali, Samir H.}
}
