@article {46995,
	title = {Highly enantioselective synthesis of sitagliptin},
	journal = {Asian Journal of Organic Chemistry},
	volume = {9},
	year = {2020},
	month = {FEB},
	pages = {189-191},
	type = {Article},
	abstract = {<p>A highly enantioselective synthesis of sitagliptin, a potent DPP-4 inhibitor, is reported. Explicitly identified chiral FerroLANE ligands in the presence of rhodium catalyze the asymmetric hydrogenation of an enamine to yield sitagliptin with excellent enantioselectivity (98\% ee). The process was scaled up to 5 g and the final product was isolated as a phosphate salt with \&gt;99\% ee.</p>
},
	keywords = {asymmetric hydrogenation, catalysis, FerroLANE ligands, Rhodium, sitagliptin},
	issn = {2193-5807},
	doi = {10.1002/ajoc.201900709, Early Access Date = JAN 2020},
	author = {Khopade, V. Kishor and Sen, Anirban and Birajdar, Rajkumar S. and Paulbudhe, Uday P. and Kavale, Dattatry S. and Shinde, Prashant S. and Mhaske, Santosh B. and Chikkali, Samir H.}
}
