@article {46818,
	title = {MnBr2-catalyzed direct and site-selective alkylation of indoles and benzo[h]quinoline},
	journal = {Organic Letters},
	volume = {22},
	year = {2020},
	month = {JUN},
	pages = {4643-4647},
	type = {Article},
	abstract = {<p>Manganese-catalyzed regioselective C-H alkylation of indoles and benzo[h]quinoline with a variety of unactivated alkyl iodides is reported. Unlike other Mn-catalyzed C-H functionalization, this protocol does not require a Grignard reagent base and employs a simple and inexpensive MnBr2 as a catalyst. This method tolerates diverse functionalities, including fluoro, chloro, bromo, iodo, alkenyl, alkynyl, pyrrolyl, and carbazolyl groups. The alkylation proceeds through a single-electron transfer pathway comprising reversible C-H manganesation and involving an alkyl radical intermediate.</p>
},
	issn = {1523-7060},
	doi = {10.1021/acs.orglett.0c01398},
	author = {Jagtap, Rahul A. and Verma, Suryadev K. and Punji, Benudhar}
}
@article {47999,
	title = {Manganese-catalyzed C(sp(2))-H alkylation of indolines and arenes with unactivated alkyl bromides},
	journal = {Chemistry-an Asian Journal},
	volume = {17},
	year = {2022},
	month = {MAY},
	pages = {e202200103},
	type = {Article},
	abstract = {<p>
	Selective C(sp(2))-H bond alkylation of indoline, carbazole and (2-pyridinyl)arenes with unactivated alkyl bromides is achieved using MnBr2 catalyst in the absence of an external ligand. The alkylation uses a simple LiHMDS base and avoids the necessity of Grignard reagent, unlike other Mn-catalyzed C-H functionalization. This reaction proceeded either through a five- or a less-favored six-membered metallacycle, and tolerated diverse functionalities, including alkenyl, alkynyl, silyl, aryl ether, pyrrolyl, indolyl, carbazolyl and alkyl bearing fatty alcohol and polycyclic-steroid moieties. Alkylation follows a single electron transfer (SET) pathway involving 1e oxidative addition of alkyl bromide and a rate-limiting C-H metalation.</p>
},
	keywords = {Alkylation, C-H activation, indoline, ligand-free, manganese},
	issn = {1861-4728},
	doi = {10.1002/asia.202200103},
	author = {Verma, Suryadev K. and Punji, Benudhar}
}
