@article {46733,
	title = {Development of a smart scaffold for sequential cancer chemotherapy and tissue engineering},
	journal = {ACS Omega},
	volume = {5},
	year = {2020},
	month = {AUG},
	pages = {20724-20733},
	type = {Article},
	abstract = {<p>The fabrication of a dual-functional drug-containing porous polymeric scaffold by layer-by-layer surface modification involving citrate-stabilized gold nanoparticles and cisplatin molecules is being reported. These scaffolds were characterized by electron microscopy and X-ray photoelectron spectroscopy. The capability of the scaffolds to release hydrated cisplatin in a slow and sustained manner over two days is established. Most importantly, the scaffolds turn nontoxic and cell-friendly after drug release, thus allowing the noncancerous fibroblast cells to adhere and proliferate (from 5000 cells to 16,000 cells in 6 days), becoming a potential solution toward an effective drug-carrying scaffold for volume-filling applications. The scaffold-mediated cancer cell killing and fibroblast cell proliferation were confirmed by fluorescence microscopy imaging, flow cytometry, and cell proliferation assays. We surmise that such a dual-purpose (drug-delivery and volume-filler) scaffold could help avoid the multiple surgical interventions needed for tumor surgery and cosmetic corrections. To the best of our knowledge, this is the first example of scaffolds with such a dual functionality which gets manifested in a sequential manner.</p>
},
	issn = {2470-1343},
	doi = {10.1021/acsomega.9b03694},
	author = {Sengupta, Poulomi and Agrawal, Vinay and Bhagavatula L. V. Prasad}
}
