@article {46649,
	title = {FeCl3-catalyzed oxidative decarboxylation of aryl/heteroaryl acetic acids: preparation of selected API impurities},
	journal = {Organic \& Biomolecular Chemistry},
	volume = {18},
	year = {2020},
	month = {NOV },
	pages = {8459-8466},
	type = {Article},
	abstract = {<p>There is an ever-increasing demand for impurity compounds for use in impurity profiling as regulatory agencies seek information during registration. Herein, we report the FeCl3-catalyzed oxidative decarboxylation of aryl- and heteroaryl acetic acids to the corresponding carbonyl compounds. A variety of useful aldehydes and ketones were prepared in a simple one-pot transformation by employing an environmentally benign, low-cost, and readily available iron salt. The utility of this method has been demonstrated by preparing five valuable API impurities including a multi-gram-scale synthesis of ketorolac impurity B for the first time.</p>
},
	issn = {1477-0520},
	doi = {10.1039/d0ob01790f},
	author = {Gangadurai, Chinnakuzhanthai and Illa, Giri Teja and Reddy, D. Srinivasa}
}
@article {46820,
	title = {Synthesis of alpha-ketoamides using potassium superoxide (KO2) as an oxidizing agent},
	journal = {Tetrahedron},
	volume = {76},
	year = {2020},
	month = {JUN },
	pages = {131262},
	type = {Article},
	abstract = {<p>A simple and convenient method for the synthesis of alpha-ketoamides by the oxidation of aryl acetamides using potassium superoxide (KO2) as an oxidizing agent is disclosed here. The scope of the developed method is successfully tested with fifteen substrates. In addition, the utility of method has been demonstrated by synthesizing an orexin receptor antagonist, a medicinally interesting compound. (C) 2020 Published by Elsevier Ltd.</p>
},
	keywords = {alpha-Ketoamide, Orexin receptor, Oxidation, Potassium superoxide (KO2)},
	issn = {0040-4020},
	doi = {10.1016/j.tet.2020.131262},
	author = {Vasudevan, N. and Routholla, Ganesh and Illa, Giri Teja and Reddy, D. Srinivasa}
}
