@article {46941, title = {Concise enantioselective synthesis of (R)-(+)-goniothalamin oxide, a trypanocidal active agent via L-prolinol catalyzed asymmetric epoxidation of cinnamaldehyde}, journal = {Indian Journal of Chemistry Section B-Organic Chemistry Including Medicinal Chemistry}, volume = {59}, year = {2020}, month = {MAR}, pages = {393-398}, type = {Article}, abstract = {

A short and straight-forward enantioselective synthesis of (R)-(+)-goniothalamin oxide 2 has been achieved with an overall yield of 39\% and 99\% ee. The synthetic approach involves L-prolinol catalyzed asymmetric epoxidation of cinnamaldehyde followed by Lewis acid-mediated diastereoselective allylation of epoxy aldehyde as the key chiral-inducing steps.

}, keywords = {Allylation, asymmetric epoxidation, Esterification, Grubbs{\textquoteright} catalyst, L-prolinol catalyst, Ring closing metathesis}, issn = {0376-4699}, author = {Kumar, B. Senthil and Mandle, Ram D. and Kamble, Sanjay P. and Sudalai, Arumugam} } @article {46610, title = {P2O5-mediated Friedel-Crafts acylation of activated arenes with carboxylic acid as acylating agent}, journal = {Indian Journal of Chemistry Section B-Organic Chemistry Including Medicinal Chemistry}, volume = {59}, year = {2020}, month = {DEC}, pages = {1861-1867}, type = {Article}, abstract = {

P2O5 has been found to be a highly efficient and environmental friendly catalyst for the liquid-phase acylation of activated aromatic substrates giving aromatic ketones (45-93\%) in a regioselective manner. Both aromatic and aliphatic carboxylic acids can be employed as acylating source. The process is particularly demonstrated at 100 g scale in the case of anisole and acetic acid to produce 4-methoxyacetophenone.

}, keywords = {4-methoxyacetophenone, Carboxylic acid, Friedel-Crafts acylations, phosphorus pentoxide}, issn = {0376-4699}, author = {Kalshetti, Rupali G. and Mandle, Ram D. and Kamble, Sanjay P. and Sudalai, Arumugam} } @article {46811, title = {Triethyl phosphite/benzoyl peroxide mediated reductive dealkylation of O-benzoylhydroxylamines: a cascade synthesis of secondary amides}, journal = {European Journal of Organic Chemistry}, volume = {2020}, year = {2020}, month = {JUL}, pages = {4235-4238}, type = {Article}, abstract = {

A new triethyl phosphite/benzoyl peroxide (BPO) mediated system has been developed for the synthesis of secondary amides with good to excellent yields in a single step. This unprecedented cascade process involves sequential reduction of N-O bond and benzoylation followed by dealkylation of N-C bond ofO-benzoylhydroxylamines (O-BHA). The methodology is versatile as it tolerates a variety of aromatic and aliphaticO-BHA as substrates to access secondary amides.

}, keywords = {Amides, Cascade reactions, O-Benzoylhydroxylamines, Redox reactions, synthetic methods}, issn = {1434-193X}, doi = {10.1002/ejoc.202000611, Early Access Date = JUN 2020}, author = {Aegurla, Balakrishna and Mandle, Ram D. and Shinde, Prasad G. and Parit, Ratan S. and Kamble, Sanjay P. and Sudalai, Arumugam and Senthilkumar, Beeran} }