@article {47687,
	title = {Photoinduced multicomponent regioselective synthesis of 1,4,5-trisubstituted-1,2,3-triazoles: transition metal-, azide- and oxidant-free protocol},
	journal = {Advanced Synthesis \& Catalysis},
	volume = {363},
	year = {2021},
	month = {JUL },
	pages = {3560-3565},
	type = {Article},
	abstract = {A transition metal- and azide-free approach is explored to synthesize 1,4,5-trisubstituted-1,2,3-triazoles under sunlight. The reaction proceeds via C-N and N-N bond formations. These regioselective 1,2,3-triazoles are obtained from isatin Schiff bases, benzaldehydes and tosylhydrazine in the presence of base. This protocol offers the structurally diverse 1,2,3-triazole derivatives with 75-90\% yields.},
	keywords = {1, 2, 3-triazoles, 4, 5-trisubstituted-1, azide- and oxidant free protocol, Cycloaddition, milder reaction conditions, molecular diversity, Multicomponent reaction, Regioselectivity, transition metal-},
	issn = {1615-4150},
	doi = {10.1002/adsc.202100321},
	author = {Sai Allaka, Bhargava and Basavoju, Srinivas and Rama Krishna, Gamidi}
}
@article {49343,
	title = {Design, synthesis, anti-mycobacterial activity, molecular docking and ADME analysis of spiroquinoxaline-1,2,4-oxadiazoles via [3+2] cycloaddition reaction under ultrasound irradiation},
	journal = {MOLECULAR DIVERSITY},
	volume = {28},
	year = {2024},
	month = {DEC 2024},
	pages = {3979-3991},
	type = {Journal Article},
	keywords = {2, 4-oxadiazoles, cytotoxicity activity, molecular, Mycobacterium tuberculosis, Spiroquinoxaline-1},
	issn = {1381-1991},
	doi = {10.1007/s11030-023-10790-9},
	author = {Kanchrana, Madhu and Gamidi, Rama Krishna and Kumari, Jyothi and Sriram, Dharmarajan and Basavoju, Srinivas}
}
@article {49930,
	title = {An ultrasound-assisted green synthesis of 1,3-diphenyl pyrazole-based spirooxindolo-1,2,4-oxadiazoles: their in vitro anti-tubercular activity and in silico molecular dynamics},
	journal = {Chemistryselect},
	volume = {10},
	year = {2025},
	month = {OCT},
	pages = {e01693},
	type = {Article},
	abstract = {<p>
	A simple base-mediated one-pot synthetic green methodology has been successfully employed for the synthesis of 1,3-diphenylpyrazole-based spirooxindolo-1,2,4-oxadiazole derivatives. The newly synthesized analogues were tested for their in vitro anti-tubercular activity (anti-TB) against Mycobacterium tuberculosis H37Rv strain, and the results were reported as minimum inhibitory concentration (MIC) values ranging from 3.125 to 25 mu g/mL. Especially, the five compounds 3a, 3f, 3k, 3q, and 3v exhibited good to moderate anti-TB activity with MIC of 3.125 mu g/mL when compared to the reference drug ethambutol (MIC: 1.56 mu g/mL). In silico Molecular docking and molecular dynamics simulations of the protein-ligand complex (3a, 3f, 3k, and 3v) against Mycobacterium tuberculosis DprE1 (PDB ID: 5OEQ) of M. tuberculosis H37Rv strain revealed that these four compounds could be promising anti-mycobacterial candidates, as evident from the binding results and stability of the docked-ligand complexes with considerable least binding energies. ADME parameters were also studied to assess the drug likeness, which clearly shows that the newly developed compounds might be useful for the future development of novel anti-tubercular drugs.</p>
},
	keywords = {1, 2, 4-oxadiazoles, In silico molecular dynamic studies, In vitro anti-tubercular activity, ultrasonication},
	issn = {2365-6549},
	doi = {10.1002/slct.202501693},
	author = {Baddepuri, Sravanthi and Gamidi, Rama Krishna and Kumari, Jyothi and Sriram, Dharmarajan and Gangarapu, Kiran and Basavoju, Srinivas}
}
