@article {48467,
	title = {Ultrasound assisted green protocol for the synthesis of quinoxaline based bisspirooxindoles: crystal structure analysis, enone umpolung, DFT calculations, anti-cancer activity, and molecular docking studies},
	journal = {Synthetic Communications},
	volume = {53},
	year = {2023},
	month = {JUN},
	pages = {835-854},
	type = {Article},
	abstract = {<p>
	A series of novel quinoxaline based bisspirooxindolo-pyrrolizidines were synthesized through 1,3-dipolar cycloaddition under ultrasonication with shorter reaction time and good yields. The compounds were well characterized by various spectroscopic methods and finally single crystal X-ray diffraction method (4c, 4d). DFT energy calculations confirm the regioselectivity due to enone umpolung effect. The in vitro anti-cancer activity of the synthesized compounds (4a-s) shows that the compounds 4g and 4q exhibited good anti-cancer activity with IC50 values14.51 +/- 1.1 and 11.36 +/- 0.23 mu M against DU-145 prostate cancer cell line; and 16.78 +/- 0.95 and 14.28 +/- 0.64 mu M against Hela cervical cancer cell lines when compared to the standard anti-cancer drug doxorubicin (1.75 +/- 0.06 and 1.35 +/- 0.09 mu M). In silico molecular docking studies indicated that the synthesized compounds may serve as a potential lead for the further development of novel anti-cancer agents.</p>
},
	keywords = {Anti-cancer activity, bisspirooxindoles, DFT calculations, Hirshfeld surface, ultrasonication},
	issn = {0039-7911},
	doi = {10.1080/00397911.2023.2199360},
	author = {Baddepuri, Sravanthi and Allaka, Bhargava Sai and Gamidi, Rama Krishna and Faizan, Mohmmad and Pawar, Ravinder and Basavoju, Srinivas}
}
@article {48296,
	title = {Ultrasound assisted synthesis of spirooxindolo-1,2,4-oxadiazoles via [3+2] cycloaddition reaction and their anti-cancer activity},
	journal = {ARKIVOC},
	year = {2023},
	month = {MAY},
	pages = {S1-S46},
	type = {Article},
	issn = {1551-7004},
	author = {Kanchrana, Madhu and Allaka, Bhargava Sai and Krishna, Gamidi Rama and Basavoju, Srinivas}
}
