@article { ISI:000229156500009,
	title = {New method for the preparation of 1,2-benzisoxazole-3-carboxaldehyde},
	journal = {Journal of Chemical Research},
	number = {2},
	year = {2005},
	month = {FEB},
	pages = {99-100},
	publisher = {SCIENCE REVIEWS LTD},
	type = {Article},
	address = {PO BOX 314, ST ALBANS AL1 4ZG, HERTS, ENGLAND},
	abstract = {<p>Synthesis of 1,2-benzisoxazole-3-carboxaldehyde is achieved from 3-methyl 1,2-benzisoxazole via 3-ethoxymethyl-1,2-benzisoxazole (4).</p>},
	keywords = {1, 2-benzisoxazoles, benzylic bromination, indoxazenes},
	issn = {0308-2342},
	author = {Kalkote, Uttam R. and Panchgalle, S. R. and Mahakal, K. K. and Choudhary, S. M. and Chavan, Sayalee R.}
}
@article { ISI:000232815200010,
	title = {Novel enzymatic route for kinetic resolution of (+/-)1,4-benzodioxan-2-carboxylic acid},
	journal = {Biochemical Engineering Journal},
	volume = {27},
	number = {1},
	year = {2005},
	month = {DEC},
	pages = {66-71},
	publisher = {ELSEVIER SCIENCE SA},
	address = {PO BOX 564, 1001 LAUSANNE, SWITZERLAND},
	abstract = {Ethyl 1,4-benzodioxan-2-carboxylate is used as an intermediate compound for the production of drug doxazosin mesylate. The title compound was kinetically resolved to get S-enantiomer of ethyl 1,4-benzodioxan 2-carboxylate in a simple lipase catalyzed transesterificafion reaction. Ethyl acetate was used as reaction medium as well as acyl donor. The influence of the enzyme source and time of reaction on the enantio selectivity of product were studied. Lipase from Candida antartica-B (Novozyme A/S) catalyzed transesterification reaction with good enantio selectivity towards S-enantiomer. The high enantiomeric ratio, E= 160, provided S-2 an acceptable chemical yield (50\%) and enaritiomeric excess (>95\%). (c) 2005 Elsevier B.V. All rights reserved.},
	keywords = {1, 4-benzodioxan-2-carboxylate, 4-benzodioxan-2-carboxylic acid, doxazosin, enantio selectivity, enantiomeric ratio, ethyl 1, ethyl acetate, Lipases, transesterfication},
	issn = {1369-703X},
	doi = {10.1016/j.bej.2005.06.014},
	author = {Kasture, Sangita M. and Varma, R and Kalkote, Uttam R. and Nene, S and Kulkarni, Bhaskar D.}
}
@article { ISI:000254798300018,
	title = {Lipases catalyzed enantioselective hydrolysis of (R,S)-methyl 1,4-benzodioxan-2-carboxylate intermediate for (S)-doxazosin mesylate},
	journal = {World Journal of Microbiology \& Biotechnology},
	volume = {24},
	number = {4},
	year = {2008},
	month = {APR},
	pages = {577-579},
	publisher = {SPRINGER},
	address = {233 SPRING STREET, NEW YORK, NY 10013 USA},
	abstract = {<p>(S)-1,4-benzodioxan-2-carboxylic acid-1 is used as starting compound for the production of the more effective (S) enantiomer of the drug doxazosin mesylate. The catalytic ability of some commercial lipases for preparations of (S) enantiomer of 1 from (+/-) methyl 1,4-benzodioxin-2-carboxylate-2 is reported. Lipases from bacterial sources were more successful in resolving the ester than those from the yeast lipases. About 85\% enantiomerically pure ester was achieved by lipase from alcaligenes sp.</p>},
	keywords = {1, 4-benzodioxan-2-carboxylate, 4-benzodioxan-2-carboxylic acid, doxazosin, Enantioselectivity, Lipases},
	issn = {0959-3993},
	doi = {10.1007/s11274-007-9504-6},
	author = {Varma, Rita and Kasture, Sangita M. and Nene, Sanjay and Kalkote, Uttam R.}
}
