@article { ISI:000227246800051, title = {Diastereoselective amidoalkylation of (3S,7aR)-6-benzyl-7-hydroxy-3-phenyltetra-hydro-5H-imidazo[1,5-c][1, 3]thiazol-5-one : a short and highly efficient synthesis of (+)-biotin}, journal = {Journal of Organic Chemistry}, volume = {70}, number = {5}, year = {2005}, month = {MAR}, pages = {1901-1903}, publisher = {AMER CHEMICAL SOC}, type = {Article}, address = {1155 16TH ST, NW, WASHINGTON, DC 20036 USA}, abstract = {

A short and highly efficient synthesis of W-biotin in 10 steps with 20\% overall yield has been achieved from L-cysteine involving amidoalkylation of hydroxy imidazothiazolone 4 via an acyliminium ion intermediate to furnish C-7-substituted imidazothiazolones 5b as the key step.

}, issn = {0022-3263}, doi = {10.1021/jo0488107}, author = {Chavan, Subhash P. and Chittiboyina, A. G. and Ravindranathan, T. and Kamat, Subhash K. and Kalkote, Uttam R.} } @article { ISI:000226332600017, title = {Efficient stereoselective synthesis of (2S,4S,5R)-(-)- and (2R,4R,5S)-(+)-bulgecinine}, journal = {Tetrahedron Letters}, volume = {46}, number = {3}, year = {2005}, month = {JAN}, pages = {439-441}, publisher = {PERGAMON-ELSEVIER SCIENCE LTD}, type = {Article}, address = {THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND}, abstract = {

A short synthetic route to (-)-and (+)-bulgecinine, the amino acid moiety of the bulgecins was achieved from the readily available nonchiral pool starting material cis-2-butene-1,4-diol in which a Claisen orthoester rearrangement and a Sharpless asymmetric dihydroxylation were used as the key steps. (C) 2004 Elsevier Ltd. All rights reserved.

}, issn = {0040-4039}, doi = {10.1016/j.tetlet.2004.11.101}, author = {Chavan, Subhash P. and Praveen, C. and Sharma, P. and Kalkote, Uttam R.} } @article { ISI:000229156500009, title = {New method for the preparation of 1,2-benzisoxazole-3-carboxaldehyde}, journal = {Journal of Chemical Research}, number = {2}, year = {2005}, month = {FEB}, pages = {99-100}, publisher = {SCIENCE REVIEWS LTD}, type = {Article}, address = {PO BOX 314, ST ALBANS AL1 4ZG, HERTS, ENGLAND}, abstract = {

Synthesis of 1,2-benzisoxazole-3-carboxaldehyde is achieved from 3-methyl 1,2-benzisoxazole via 3-ethoxymethyl-1,2-benzisoxazole (4).

}, keywords = {1, 2-benzisoxazoles, benzylic bromination, indoxazenes}, issn = {0308-2342}, author = {Kalkote, Uttam R. and Panchgalle, S. R. and Mahakal, K. K. and Choudhary, S. M. and Chavan, Sayalee R.} } @article { ISI:000232815200010, title = {Novel enzymatic route for kinetic resolution of (+/-)1,4-benzodioxan-2-carboxylic acid}, journal = {Biochemical Engineering Journal}, volume = {27}, number = {1}, year = {2005}, month = {DEC}, pages = {66-71}, publisher = {ELSEVIER SCIENCE SA}, address = {PO BOX 564, 1001 LAUSANNE, SWITZERLAND}, abstract = {Ethyl 1,4-benzodioxan-2-carboxylate is used as an intermediate compound for the production of drug doxazosin mesylate. The title compound was kinetically resolved to get S-enantiomer of ethyl 1,4-benzodioxan 2-carboxylate in a simple lipase catalyzed transesterificafion reaction. Ethyl acetate was used as reaction medium as well as acyl donor. The influence of the enzyme source and time of reaction on the enantio selectivity of product were studied. Lipase from Candida antartica-B (Novozyme A/S) catalyzed transesterification reaction with good enantio selectivity towards S-enantiomer. The high enantiomeric ratio, E= 160, provided S-2 an acceptable chemical yield (50\%) and enaritiomeric excess (>95\%). (c) 2005 Elsevier B.V. All rights reserved.}, keywords = {1, 4-benzodioxan-2-carboxylate, 4-benzodioxan-2-carboxylic acid, doxazosin, enantio selectivity, enantiomeric ratio, ethyl 1, ethyl acetate, Lipases, transesterfication}, issn = {1369-703X}, doi = {10.1016/j.bej.2005.06.014}, author = {Kasture, Sangita M. and Varma, R and Kalkote, Uttam R. and Nene, S and Kulkarni, Bhaskar D.} } @article { ISI:000228267300014, title = {Simple, concise, stereocontrolled synthesis of (8E,10Z)-pentadecadien-1-ol acetate}, journal = {Synthetic Communications}, volume = {35}, number = {7}, year = {2005}, month = {AUG}, pages = {987-994}, publisher = {TAYLOR \& FRANCIS INC}, type = {Article}, address = {325 CHESTNUT ST, SUITE 800, PHILADELPHIA, PA 19106 USA}, abstract = {

A simple, concise, and stereocontrolled synthesis of (8E, 10Z)-pentadecadien-l -ol acetate involving a Cadiot-Chodkiewicz reaction as the key step is described.

}, keywords = {acetate, Acrobasis vaccini, Cadiot-Chodkiewicz reaction, diacetylene, Pheromone}, issn = {0039-7911}, doi = {10.1081/SCC-200051715}, author = {Chavan, Subhash P. and Kharul, Rajendra K. and Kamat, Subhash K. and Kalkote, Uttam R. and Kale, R. R.} } @article { ISI:000237886100006, title = {Convenient chemoenzymatic synthesis of (1S,7aS)-1-hydroxy-5-oxo-4-(2 {\textquoteleft}-carboxyethyl)-7a-methyltetrahydro-indane - a key intermediate of steroids}, journal = {Journal of Molecular Catalysis B-Enzymatic}, volume = {40}, number = {1-2}, year = {2006}, month = {MAY}, pages = {38-43}, publisher = {ELSEVIER SCIENCE BV}, type = {Article}, address = {PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS}, abstract = {

A porcine pancreatic lipase mediated enzymatic hydrolysis of (+/-)-1-acetoxy-5-oxo-4-(2 {\textquoteleft}-carbomethoxyethyl)-7a-methyltetrahydroindane (5b) furnished (1S,7aS)-1-acetoxy-5-oxo-4-(2 {\textquoteleft}-carbomethoxyethyl)-7a-methyltetrahydro-indane (9) and (1R,7aR)-1-hydroxy-5-oxo-4-(2 {\textquoteleft}-carbomethoxyethyl)-7a-methyltetrahydro-indane (8) with \> 99\% e.e. which on further chemical hydrolysis gave 1 and ent-1, key intermediates of steroids. (c) 2006 Elsevier B.V. All rights reserved.

}, keywords = {chemoenzymatic method, Enzymatic hydrolysis, steroids, terpenoids}, issn = {1381-1177}, doi = {10.1016/j.molcatb.2006.01.037}, author = {Kalkote, Uttam R. and Purude, A. N. and Puranik, Vedavati G. and Gurjar, M. K.} } @article { ISI:000241755300045, title = {First enantiospecific synthesis of (-)-parvifoline and (-)-curcuquinone}, journal = {Journal of Organic Chemistry}, volume = {71}, number = {23}, year = {2006}, month = {NOV}, pages = {8986-8988}, publisher = {AMER CHEMICAL SOC}, type = {Article}, address = {1155 16TH ST, NW, WASHINGTON, DC 20036 USA}, abstract = {

The first enantiospecific synthesis of (-)-parvifoline, employing ring-closing metathesis as the key step, and (-)-curcuquinone from naturally occurring (R)-(+)-citronellal is described.

}, issn = {0022-3263}, doi = {10.1021/jo061730d}, author = {Chavan, Subhash P. and Thakkar, Mahesh and Jogdand, Ganesh F. and Kalkote, Uttam R.} } @article { ISI:000242873400029, title = {Ring closing metathesis approach to the indole alkaloid mitralactonine}, journal = {Tetrahedron Letters}, volume = {47}, number = {52}, year = {2006}, month = {DEC}, pages = {9301-9303}, publisher = {PERGAMON-ELSEVIER SCIENCE LTD}, type = {Article}, address = {THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND}, abstract = {

An efficient utilisation of RCM leading to a convenient synthesis of a pentacyclic indole alkaloid is described. (c) 2006 Elsevier Ltd. All rights reserved.

}, keywords = {corynanthe type alkaloid, Dihydroxylation, mitralactonine, RCM, Swern oxidation}, issn = {0040-4039}, doi = {10.1016/j.tetlet.2006.10.106}, author = {Chavan, Subhash P. and Sharma, Pallavi and Sivappa, R. and Kalkote, Uttam R.} } @article { ISI:000249894100012, title = {Convenient formal synthesis of (+/-)-paroxetine}, journal = {Synthetic Communications}, volume = {37}, number = {18}, year = {2007}, month = {SEP}, pages = {3143-3149}, publisher = {TAYLOR \& FRANCIS INC}, type = {Article}, address = {325 CHESTNUT ST, SUITE 800, PHILADELPHIA, PA 19106 USA}, abstract = {

A formal total synthesis of antidepressant (+/-)-paroxetine employing a solvent-free Heck reaction is disclosed.

}, keywords = {antidepressants, carbamate, electrophile, Heck reaction, piperidines}, issn = {0039-7911}, doi = {10.1080/00397910701545130}, author = {Chavan, Subhash P. and Khobragade, Dushant A. and Pathak, Ashok B. and Kalkote, Uttam R.} } @article { ISI:000252219700011, title = {Efficient and practical total synthesis of (+/-)-alpha-cuparenone}, journal = {Synthesis-Stuttgart }, number = {24}, year = {2007}, month = {DEC}, pages = {3827-3830}, publisher = {GEORG THIEME VERLAG KG}, type = {Article}, address = {RUDIGERSTR 14, D-70469 STUTTGART, GERMANY}, abstract = {

A one-pot cyclopentannulation approach as the key step for the total synthesis of (+/-)-alpha-cuparenone is described.

}, keywords = {Alkylation, annulation, hydroboration-oxidation, reduction}, issn = {0039-7881}, doi = {10.1055/s-2007-990899}, author = {Chavan, Subhash P. and Dhawane, Abasaheb N. and Kalkote, Uttam R.} } @article { ISI:000243819800014, title = {Facile total synthesis of (+/-)-alpha-cuparenone employing diallylation and RCM as key steps}, journal = {Tetrahedron Letter}, volume = {48}, number = {6}, year = {2007}, month = {FEB}, pages = {965-966}, publisher = {PERGAMON-ELSEVIER SCIENCE LTD}, type = {Article}, address = {THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND}, abstract = {

A short and concise total synthesis of alpha-cuparenone employing one-pot diallylation and RCM as the key steps is described. (c) 2006 Elsevier Ltd. All rights reserved.

}, issn = {0040-4039}, doi = {10.1016/j.tetlet.2006.12.023}, author = {Chavan, Subhash P. and Dhawane, Abasaheb N. and Kalkote, Uttam R.} } @article { ISI:000243704000028, title = {First enantiospecific synthesis of (-)-heritol: absolute configuration determination}, journal = {Tetrahedron Letters}, volume = {48}, number = {4}, year = {2007}, month = {JAN}, pages = {643-646}, publisher = {PERGAMON-ELSEVIER SCIENCE LTD}, type = {Article}, address = {THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND}, abstract = {

The first enantiospecific synthesis of (-)-heritol, from naturally occurring (R)-(+)-citronellal and confirmation of its absolute configuration, is described. (c) 2006 Elsevier Ltd. All rights reserved.

}, issn = {0040-4039}, doi = {10.1016/j.tetlet.2006.11.123}, author = {Chavan, Subhash P. and Thakkar, Mahesh and Kalkote, Uttam R.} } @article { ISI:000244257400014, title = {Practical and facile approach towards indole alkaloids: (-)-mitralactonine}, journal = {Synlett}, number = {1}, year = {2007}, month = {JAN}, pages = {79-82}, publisher = {GEORG THIEME VERLAG KG}, type = {Article}, address = {RUDIGERSTR 14, D-70469 STUTTGART, GERMANY}, abstract = {

An efficient approach to (-)-mitralactonine using Pictet-Spengler cyclisation with a highly functionalised masked aldehyde is described. Sharpless asymmetric dihydroxylation (SAD) is utilised to introduce chirality in the key substrate.

}, keywords = {alkaloids, asymmetric, cyclisations, dihydroxylations, thioacetats}, issn = {0936-5214}, doi = {10.1055/s-2006-958434}, author = {Chavan, Subhash P. and Sharma, Pallavi and Sivappa, Rasapalli and Kalkote, Uttam R.} } @article { ISI:000249627100033, title = {Practical formal synthesis of camptothecin}, journal = {Tetrahedron Letter}, volume = {48}, number = {37}, year = {2007}, month = {SEP}, pages = {6561-6563}, publisher = {PERGAMON-ELSEVIER SCIENCE LTD}, type = {Article}, address = {THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND}, abstract = {

The synthesis of the DE ring of camptothecin using simple and inexpensive starting materials, employing an addition elimination reaction and selective esterification of an aliphatic carboxylic acid as key steps is described. (C) 2007 Elsevier Ltd. All rights reserved.

}, keywords = {alkaloid, Anticancer, camptothecin, Natural product}, issn = {0040-4039}, doi = {10.1016/j.tetlet.2007.07.017}, author = {Chavan, Subhash P. and Pathak, Ashok B. and Kalkote, Uttam R.} } @article { ISI:000252029800002, title = {Practical synthesis of (+/-)-venlafaxine}, journal = {Synthetic Communications}, volume = {37}, number = {22-24}, year = {2007}, month = {NOV}, pages = {3901-3906}, publisher = {TAYLOR \& FRANCIS INC}, type = {Article}, address = {325 CHESTNUT ST, SUITE 800, PHILADELPHIA, PA 19106 USA}, abstract = {

A practical total synthesis of antidepressant (+/-)-venlafaxine is disclosed.

}, keywords = {antidepressant, Grignard reaction, Michael addition}, issn = {0039-7911}, doi = {10.1080/00397910701572266}, author = {Chavan, Subhash P. and Khobragade, Dushant A. and Thakkar, Mahesh and Kalkote, Uttam R.} } @article { ISI:000252029800038, title = {Short and efficient synthesis of rubrolide E}, journal = {Synthetic Communications}, volume = {37}, number = {22-24}, year = {2007}, month = {DEC}, pages = {4253-4263}, publisher = {TAYLOR \& FRANCIS INC}, type = {Article}, address = {325 CHESTNUT ST, SUITE 800, PHILADELPHIA, PA 19106 USA}, abstract = {

Short and efficient synthesis of rubrolide E from commercially available 4-methoxyacetophenone, employing ring-closing metathesis, Knoevenagel condensation, and Reformatsky reactions, are the key steps are described.

}, keywords = {antibiotics, antitumor, Epoxide, Natural products, Total synthesis}, issn = {0039-7911}, doi = {10.1080/00397910701575665}, author = {Chavan, Subhash P. and Pathak, Ashok B. and Pandey, Ankur and Kalkote, Uttam R.} } @article { ISI:000250836500003, title = {Total synthesis of (+)-camptothecin via an intramolecular palladium-catalyzed cyclization strategy}, journal = {Synlett}, number = {17}, year = {2007}, month = {OCT}, pages = {2635-2638}, publisher = {GEORG THIEME VERLAG KG}, type = {Article}, address = {RUDIGERSTR 14, D-70469 STUTTGART, GERMANY}, abstract = {

The novel cascade intramolecular Pd-catalyzed cyclization followed by aromatization for the construction Of D ring of (+)-camptothecin as a key step is demonstrated.

}, keywords = {alkaloids, antitumor, cyclizations, Natural products, Palladium}, issn = {0936-5214}, doi = {10.1055/s-2007-991054}, author = {Chavan, Subhash P. and Pathak, Ashok B. and Kalkote, Uttam R.} } @article { ISI:000247620500052, title = {Total synthesis of pulchellalactam via an RCM strategy}, journal = {Synthetic Communications}, volume = {37}, number = {7-9}, year = {2007}, month = {MAY}, pages = {1503-1510}, publisher = {TAYLOR \& FRANCIS INC}, type = {Article}, address = {325 CHESTNUT ST, SUITE 800, PHILADELPHIA, PA 19106 USA}, abstract = {

Total synthesis of (Z) pulchellalactam, a CD protein tyrosine phosphatase inhibitor, from commercially available methallyl chloride employing ring-closure metathesis (RCM) as a key step is described.

}, keywords = {alkaloid, Natural products, pulchellalactam, RCM, Total synthesis}, issn = {0039-7911}, doi = {10.1080/00397910701229131}, author = {Chavan, Subhash P. and Pathak, Ashok B. and Dhawane, Abasaheb N. and Kalkote, Uttam R.} } @article { ISI:000254798300018, title = {Lipases catalyzed enantioselective hydrolysis of (R,S)-methyl 1,4-benzodioxan-2-carboxylate intermediate for (S)-doxazosin mesylate}, journal = {World Journal of Microbiology \& Biotechnology}, volume = {24}, number = {4}, year = {2008}, month = {APR}, pages = {577-579}, publisher = {SPRINGER}, address = {233 SPRING STREET, NEW YORK, NY 10013 USA}, abstract = {

(S)-1,4-benzodioxan-2-carboxylic acid-1 is used as starting compound for the production of the more effective (S) enantiomer of the drug doxazosin mesylate. The catalytic ability of some commercial lipases for preparations of (S) enantiomer of 1 from (+/-) methyl 1,4-benzodioxin-2-carboxylate-2 is reported. Lipases from bacterial sources were more successful in resolving the ester than those from the yeast lipases. About 85\% enantiomerically pure ester was achieved by lipase from alcaligenes sp.

}, keywords = {1, 4-benzodioxan-2-carboxylate, 4-benzodioxan-2-carboxylic acid, doxazosin, Enantioselectivity, Lipases}, issn = {0959-3993}, doi = {10.1007/s11274-007-9504-6}, author = {Varma, Rita and Kasture, Sangita M. and Nene, Sanjay and Kalkote, Uttam R.} } @article { ISI:000261466800007, title = {Tandem aza-michael-condensation-aldol cyclization reaction: approach to the construction of DE synthon of (+/-)-camptothecin}, journal = {Synlett}, number = {18}, year = {2008}, month = {NOV}, pages = {2781-2784}, publisher = {GEORG THIEME VERLAG KG}, type = {Article}, address = {RUDIGERSTR 14, D-70469 STUTTGART, GERMANY}, abstract = {

An efficient synthesis of the DE ring of camptothecin, employing a Reformatsky and a tandem one-pot, three-step transformation involving aza-Michael reaction, condensation with ethyl malonyl chloride followed by intramolecular {\textquoteleft}aldol{\textquoteright} reaction to furnish the dihydropyridone derivative from commercially available starting materials, has been achieved.

}, keywords = {Aldol cyclizations, alkaloids, antitumor, Natural products, Reformatsky reaction}, issn = {0936-5214}, doi = {10.1055/s-0028-1083539}, author = {Chavan, Subhash P. and Dhawane, Abasaheb N. and Kalkote, Uttam R.} } @article { ISI:000270126100012, title = {Organocatalytic enantioselective synthesis of beta-blockers: (S)-propranolol and (S)-naftopidil}, journal = {Tetrahedron-Asymmetry}, volume = {20}, number = {15}, year = {2009}, month = {AUG}, pages = {1767-1770}, publisher = {PERGAMON-ELSEVIER SCIENCE LTD}, address = {THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND}, abstract = {

An efficient enantioselective synthesis of beta-adrenergic blockers (S)-propranolol and (S)-naftopidil with \> 98\% ee using an L-proline-catalyzed alpha-aminoxylation of an aldehyde as a key step is described. (c) 2009 Elsevier Ltd. All rights reserved.

}, issn = {0957-4166}, doi = {10.1016/j.tetasy.2009.07.002}, author = {Panchgalle, Sharad P. and Gore, Rohitkumar G. and Chavan, Subhash P. and Kalkote, Uttam R.} } @article { ISI:000264490200027, title = {Studies toward the total synthesis of carba analogue of motif C OF M. TB cell wall AG complex}, journal = {Heterocycles}, volume = {77}, number = {2}, year = {2009}, month = {FEB}, pages = {909-925}, publisher = {PERGAMON-ELSEVIER SCIENCE LTD}, address = {THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND}, abstract = {

Herein we describe the synthesis of the carba analogue of motif C of arabinogalactan complex present in M tuberculosis cell wall. Pd(0) catalyzed allylic alkylation and Fraser-Reid{\textquoteright}s glycosidation are the two key reactions that were employed for the synthesis of central glycosyl accepter unit and the glycosylation respectively.

}, keywords = {Allylic Alkylation, desymmetrization, Fraser-Reid{\textquoteright}s Glycosidation, M. Tb Ag Complex, Mycobacterium tuberculosis}, issn = {0385-5414}, doi = {10.3987/COM-08-S(F)59}, author = {Gurjar, Mukund K. and Reddy, Challa Nageswar and Kalkote, Uttam R. and Chorghade, Mukund S.} } @article { ISI:000278985800034, title = {Enantioselective synthesis of (R)-(+)-alpha-lipoic acid via proline-catalyzed sequential alpha-aminoxylation and HWE olefination of aldehyde}, journal = {Tetrahedron Letters}, volume = {51}, number = {27}, year = {2010}, month = {JUL}, pages = {3587-3589}, publisher = {PERGAMON-ELSEVIER SCIENCE LTD}, address = {THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND}, abstract = {

An efficient enantioselective synthesis of (R)-(+)-alpha-lipoic acid is described, in high optical purity (\>97\% ee), using L-proline-catalyzed sequential alpha-aminoxylation and Horner-Wadsworth-Emmons olefination of aldehyde as the key step. (C) 2010 Elsevier Ltd. All rights reserved.

}, issn = {0040-4039}, doi = {10.1016/j.tetlet.2010.05.007}, author = {Panchgalle, Sharad P. and Jogdand, Ganesh F. and Chavan, Subhash P. and Kalkote, Uttam R.} } @article { ISI:000278451000017, title = {Formal synthesis of (+/-)-camptothecin via tricyclic lactone as key synthon}, journal = {Tetrahedron Letters}, volume = {51}, number = {23}, year = {2010}, month = {JUN}, pages = {3099-3101}, publisher = {PERGAMON-ELSEVIER SCIENCE LTD}, address = {THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND}, abstract = {

Formal synthesis of (+/-)-camptothecin via CDE tricyclic lactone employing tandem Michael addition, Dieckmann condensation and addition-elimination reaction as key steps starting from glycinate is described. (C) 2010 Elsevier Ltd. All rights reserved.

}, issn = {0040-4039}, doi = {10.1016/j.tetlet.2010.04.019}, author = {Chavan, Subhash P. and Dhawane, Abasaheb N. and Kalkote, Uttam R.} } @article { ISI:000284728400014, title = {Organocatalytic asymmetric synthesis of (-)-delta-coniceine based on sequential proline-catalyzed asymmetric alpha-amination-HWE olefination}, journal = {Tetrahedron-Asymmetry}, volume = {21}, number = {19}, year = {2010}, month = {OCT}, pages = {2399-2401}, publisher = {PERGAMON-ELSEVIER SCIENCE LTD}, address = {THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND}, abstract = {

An efficient asymmetric synthesis of (-)-delta-coniceine via sequential proline-catalyzed asymmetric alpha-amination and Horner-Wadsworth-Emmons olefination of an aldehyde with excellent enantiomeric excess (\>99\%) and high yields (overall yield 44\%) is described. (C) 2010 Elsevier Ltd. All rights reserved.

}, issn = {0957-4166}, doi = {10.1016/j.tetasy.2010.08.009}, author = {Panchgalle, Sharad P. and Bidwai, Harshad B. and Chavan, Subhash P. and Kalkote, Uttam R.} } @article { ISI:000286862200012, title = {Asymmetric total synthesis of (2S,3S)-3-hydroxypipecolic acid}, journal = {Tetrahedron Letters}, volume = {52}, number = {3}, year = {2011}, month = {JAN}, pages = {404-406}, publisher = {PERGAMON-ELSEVIER SCIENCE LTD}, address = {THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND}, abstract = {

A synthetic route to (2S,3S)-3-hydroxypipecolic acid was achieved from readily available nonchiral pool starting material cis-2-butene-1,4-diol and involved Claisen orthoester rearrangement, Sharpless asymmetric dihydroxylation and intramolecular lactamisation of azido lactone as the key steps. (C) 2010 Elsevier Ltd. All rights reserved.

}, issn = {0040-4039}, doi = {10.1016/j.tetlet.2010.11.062}, author = {Chavan, Subhash P. and Dumare, Nilesh B. and Harale, Kishor R. and Kalkote, Uttam R.} } @article { ISI:000291139700014, title = {Convenient formal synthesis of (2S,3S)-3-hydroxy pipecolic acid}, journal = {Tetrahedron-Asymmetry}, volume = {22}, number = {5}, year = {2011}, month = {MAR}, pages = {587-590}, publisher = {PERGAMON-ELSEVIER SCIENCE LTD}, address = {THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND}, abstract = {

A convenient synthesis of (2S,3S)-3-hydroxy pipecolic acid starting from inexpensive and easily available L-(+)-tartaric acid has been described. (C) 2011 Elsevier Ltd. All rights reserved.

}, issn = {0957-4166}, doi = {10.1016/j.tetasy.2011.02.023}, author = {Chavan, Subhash P. and Harale, Kishor R. and Dumare, Nilesh B. and Kalkote, Uttam R.} } @article { ISI:000290409100007, title = {Exploration of L-proline-catalyzed -aminoxylation of aldehyde to (S)-guaifenesin-related drug molecules}, journal = {Synthetic Communications}, volume = {41}, number = {13}, year = {2011}, month = {MAY}, pages = {PII 937137930}, publisher = {TAYLOR \& FRANCIS INC}, address = {325 CHESTNUT ST, SUITE 800, PHILADELPHIA, PA 19106 USA}, abstract = {

[image omitted] An efficient enantioselective synthesis of (S)-guaifenesin with 99\% ee using L-proline-catalyzed -aminoxylation of aldehyde as key step is described and explored for asymmetric syntheses of (S)-moprolol and (R)-methocarbamol.

}, keywords = {-Aminoxylation, guaifenesin, methocarbamol, moprolol, Proline}, issn = {0039-7911}, doi = {10.1080/00397911.2010.493631}, author = {Panchgalle, Sharad P. and Kunte, Sunita S. and Chavan, Subhash P. and Kalkote, Uttam R.} } @article { ISI:000308778100017, title = {Highly diastereoselective total synthesis of (+/-)-heritonin and (+/-)-heritol}, journal = {Tetrahedron}, volume = {68}, number = {40}, year = {2012}, month = {OCT}, pages = {8509-8514}, publisher = {PERGAMON-ELSEVIER SCIENCE LTD}, address = {THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND}, abstract = {

A highly diastereoselective synthesis of heritol and heritonin by intramolecular cyclization on a preformed sensitive butenolide functionality is described. (C) 2012 Elsevier Ltd. All rights reserved.

}, keywords = {Butenolide, cyclization, Dihydroxylation, Friedel-Crafts acylation, Tetralone}, issn = {0040-4020}, doi = {10.1016/j.tet.2012.07.020}, author = {Chavan, Subhash P. and Garai, Sumanta and Kalkote, Uttam R.} } @article { ISI:000352671600006, title = {Total synthesis of (R)-lipoic acid and (S)-lipoic acid via an Mn (III)-salen-catalyzed oxidative kinetic resolution}, journal = {Tetrahedron-Asymmetry}, volume = {26}, number = {5-6}, year = {2015}, month = {MAR}, pages = {281-287}, publisher = {PERGAMON-ELSEVIER SCIENCE LTD}, address = {THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND}, abstract = {

The asymmetric synthesis of both the antipodes of alpha-lipoic acid is described. The total synthesis of racemic and asymmetric lipoic acid is achieved from propane 1,3-diol. This work reports the use of Mn (III)-salen-catalyzed oxidative kinetic resolution as the key step to obtain enantiomerically pure (R)- and (S)-lipoic acid. The undesired product formed during the resolution can be recycled to achieve the desired isomer. (C) 2015 Elsevier Ltd. All rights reserved.

}, issn = {0957-4166}, doi = {10.1016/j.tetasy.2015.02.001}, author = {Purude, Abhijeet N. and Pawar, Kailash P. and Patil, Niteen B. and Kalkote, Uttam R. and Chavan, Subhash P.} }