@article { ISI:000227246800051,
	title = {Diastereoselective amidoalkylation of (3S,7aR)-6-benzyl-7-hydroxy-3-phenyltetra-hydro-5H-imidazo[1,5-c][1, 3]thiazol-5-one : a short and highly efficient synthesis of (+)-biotin},
	journal = {Journal of Organic Chemistry},
	volume = {70},
	number = {5},
	year = {2005},
	month = {MAR},
	pages = {1901-1903},
	publisher = {AMER CHEMICAL SOC},
	type = {Article},
	address = {1155 16TH ST, NW, WASHINGTON, DC 20036 USA},
	abstract = {<p>A short and highly efficient synthesis of W-biotin in 10 steps with 20\% overall yield has been achieved from L-cysteine involving amidoalkylation of hydroxy imidazothiazolone 4 via an acyliminium ion intermediate to furnish C-7-substituted imidazothiazolones 5b as the key step.</p>},
	issn = {0022-3263},
	doi = {10.1021/jo0488107},
	author = {Chavan, Subhash P. and Chittiboyina, A. G. and Ravindranathan, T. and Kamat, Subhash K. and Kalkote, Uttam R.}
}
@article {47097,
	title = {Divergent approach to the synthesis of (-)-balanol heterocycle and cis-3-hydroxypipecolic acid based on chiral 2-aminoalkanol equivalent},
	journal = {Tetrahedron},
	volume = {80},
	year = {2021},
	month = {JAN},
	pages = {131773},
	type = {Article},
	abstract = {<p>Enantioselective synthesis of the hexahydroazepine core of (-)-balanol and formal synthesis of cis-3hydroxypipecolic acid from a common intermediate have been accomplished by a divergent path. The common intermediate was accessed from a favorably protected enantiomerically pure 2-amino-1,3,4-butanetriol (ABT) equivalent via oxidation and Wittig olefination. The synthesis of (-)-balanol heterocycle featured tandem reduction/acetal-deprotection/gamma-lactonization reaction and a one-pot azide reduction followed by seven membered aza-heterocycle formation while the route to cis-3-hydroxypipecolic acid highlighted the base induced piperidine ring formation and regioselective benzylidine-acetal cleavage. (C) 2020 Elsevier Ltd. All rights reserved.</p>
},
	keywords = {Amino-alcohol, desymmetrization, Hexahydroazepine, Piperidine alkaloids, Protein kinase},
	issn = {0040-4020},
	doi = {10.1016/j.tet.2020.131773},
	author = {Chavan, Subhash P. and Kalbhor, Dinesh B. and Gonnade, Rajesh G.}
}
