@article { ISI:000231782100007,
	title = {Unusual stereochemical outcome of radical cyclization: synthesis of (+)-biotin},
	journal = {Tetrahedron},
	volume = {61},
	number = {39},
	year = {2005},
	month = {SEP},
	pages = {9273-9280},
	publisher = {PERGAMON-ELSEVIER SCIENCE LTD},
	type = {Article},
	address = {THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND},
	abstract = {<p>An enantioselective synthesis of (+)-biotin 1 starting from naturally available cysteine is described. The key steps are the unusual stereochemical outcome of radical cyclization of compound 10 to prepare 5,5-fused system 11, and the introduction of C4-sidechain at C-6 in 13 via a Grignard reaction. (c) 2005 Elsevier Ltd. All rights reserved.</p>},
	keywords = {biotin, exocyclization, radical cyclization},
	issn = {0040-4020},
	doi = {10.1016/j.tet.2005.07.070},
	author = {Chavan, Subhash P. and Chittiboyina, A. G. and Ramakrishna, G. and Tejwani, R. B. and Ravindranathan, T. and Kamat, Subhash K. and Rai, B. and Sivadasan, L. and Balakrishnan, K. and Ramalingam, S. and Deshpande, V. H.}
}
@article { ISI:000345902500007,
	title = {Facile and convenient synthesis of (+/-)-Biotin via MgCl2/Et3N-mediated C-C coupling and mitsunobu reaction},
	journal = {Synlett},
	volume = {25},
	number = {20},
	year = {2014},
	month = {DEC},
	pages = {2879-2882},
	publisher = {GEORG THIEME VERLAG KG},
	type = {Article},
	address = {RUDIGERSTR 14, D-70469 STUTTGART, GERMANY},
	abstract = {<p>A synthesis of (+/-)-biotin is described starting from simple starting materials viz. cyclohexanone and amino malonic acid ester. The key steps involved are MgCl2/Et3N coupling of amino malonic acid ester derivative and acid chloride, Mitsunobu reaction, ozonolysis, Staudinger reduction, novel urea formation, and subsequent dibenzylation. This approach is economical and involves high-yielding steps and simple reaction conditions.</p>},
	keywords = {Appel reaction, biotin, Mitsunobu reaction, Ozonolysis, Staudinger reduction},
	issn = {0936-5214},
	doi = {10.1055/s-0034-1379365},
	author = {Chavan, Subhash P. and Chavan, Prakash N. and Lasonkar, Pradeep B. and Khairnar, Lalit B. and Kadam, Appasaheb L.}
}
