@article { ISI:000351584500007,
	title = {Synthesis of 3-ethyl-4-metyl-1h,5-dihydro-2h-pyrrol-2-one by novel palladium(ii)-catalyzed cyclization and ring-closing metathesis},
	journal = {Synthesis-Stuttgart},
	volume = {47},
	number = {7},
	year = {2015},
	month = {APR},
	pages = {955-960},
	publisher = {GEORG THIEME VERLAG KG},
	type = {Article},
	address = {RUDIGERSTR 14, D-70469 STUTTGART, GERMANY},
	abstract = {<p>Synthesis of 3-ethyl-4-methyl-1,5-dihydro-2H-pyrrol-2-one is described starting from commercially available allylamine and 4-methoxybenzylamine employing palladium-catalyzed cyclization or ring-closing metathesis as the key steps.</p>},
	keywords = {antidiabetic, cyclization, glimepiride, lactams, metabolite, pyrrolinone, Ring-closing metathesis},
	issn = {0039-7881},
	doi = {10.1055/s-0034-1379985},
	author = {Chavan, Subhash P. and Pathak, Ashok B. and Pawar, Kailash P.}
}
@article {46634,
	title = {Scalable synthesis of 3-Ethyl-4-methyl-1,5-dihydro-2H-pyrrol-2-one: an important building block of the antidiabetic drug glimepiride},
	journal = {Synthesis-Stuttgart},
	volume = {52},
	year = {2020},
	month = {NOV},
	pages = {3480-3484},
	type = {Article},
	abstract = {<p>A four-step, practical, and easily scalable synthesis of 3-ethyl-4-methyl-1,5-dihydro-2H-pyrrol-2-one, an important building block of the antidiabetic drug glimepiride, has been accomplished. Key features are the synthesis of 3-methyl-4-hydroxy-2-butenolide in water and triflic acid mediated N-benzyl lactam N-deprotection. The main advantages of this process are the scalable synthetic route and decreased number of reaction steps, which paves the way for the industrial-scale synthesis of 3-ethyl-4-methyl-1,5-dihydro-2H-pyrrol-2-one.</p>
},
	keywords = {antidiabetic drug, Butenolide, glimepiride, lactams, scalable synthesis},
	issn = {0039-7881},
	doi = {10.1055/s-0040-1707344},
	author = {Chavan, Subhash P. and Pawar, Ambaji A. and Patil, Niteen B. and Kadam, Appasaheb L. and Shinde, Shrikrishna S.}
}
