@article {46992,
	title = {Furan-derived chiral bicycloaziridino lactone synthon: collective syntheses of oseltamivir phosphate (Tamiflu), (S)-pipecolic acid and its 3-hydroxy derivatives},
	journal = {Chemistry-An Asian Journal},
	volume = {15},
	year = {2020},
	month = {FEB },
	pages = {415-424},
	type = {Article},
	abstract = {<p>A unified synthetic strategy for oseltamivir phosphate (tamiflu), (S)-pipecolic acid, and its 3-hydroxy derivatives from furan derived common chiral bicycloaziridino lactone synthon is described here. Key features are the short (4-steps), enantiopure, and decagram-scale synthesis of common chiral synthon from furan and its first-ever application in the total synthesis of biologically active compounds by taking the advantages of high functionalization ability of chiral synthon.</p>
},
	keywords = {Aziridine synthon, Chiral auxiliary, collective synthesis, Pipecolic acid, Tamiflu},
	issn = {1861-4728},
	doi = {10.1002/asia.201901523, Early Access Date = JAN 2020},
	author = {Chavan, Subhash P. and Kadam, Appasaheb L. and Shinde, Shrikrishna S. and Gonnade, Rajesh G.}
}
@article {48009,
	title = {cis-aziridine synthon based synthetic investigation for tamiflu employing horner-wadsworth-emmons reaction},
	journal = {European Journal of Organic Chemistry},
	volume = {2022},
	year = {2022},
	month = {JUL },
	pages = {e202200384},
	type = {Article},
	abstract = {<p>
	Synthetic investigations to achieve a novel intermediate of Tamiflu by using cis-aziridine as a chiral building block, which is readily synthesized from (D)-mannitol as a renewable starting material, has been presented. The present approach utilizes the intramolecular Horner-Wadsworth-Emmons reaction as the key step for the synthesis of Tamiflu. On the other hand, diene containing allylic aziridine framework is found to be inefficient to furnish the six-membered core skeleton of Tamiflu through ring-closing metathesis reaction.</p>
},
	keywords = {Aziridine, cyclization, HWE reaction, Metathesis, Tamiflu},
	issn = {1434-193X},
	doi = {10.1002/ejoc.202200384},
	author = {Chavan, Subhash P. and Kawale, Sanket A. and Gonnade, Rajesh G.}
}
