@article {47398,
	title = {Advances in transition-metal-catalyzed C-H bond oxygenation of amides},
	journal = {Synthesis-Stuttgart},
	year = {2021},
	month = {APR },
	type = {Article; Early Access},
	abstract = {<p>C-O bond formation represents a fundamental chemical transformation in organic synthesis to develop valuably oxygenated (hetero)arenes. Particularly, the direct and regioselective C-H bond oxygenation of privileged amides, using a transition metal catalyst and a mild oxygenating source, is a step-economy and attractive approach. During the last decade, considerable progress has been realized in the direct C-H oxygenation of primary, secondary, and tertiary amides. This Short Review compiles the advances in transition-metal-catalyzed oxygenation of C(sp(2))-H and C(sp(3))-H bonds on various amides with diverse oxygenation sources. The review is categorized into two different major sections: (i) C(sp(2))-H oxygenation and (ii) C(sp(3))-H oxygenation. Each section is discussed based on the directing group (monodentate and bidentate) attached to the amide derivatives.</p>},
	keywords = {Amides, C-H activation, directing group, Oxygenation, Transition Metal},
	issn = {0039-7881},
	doi = {10.1055/a-1481-2584, Early Access Date = APR 2021},
	author = {Vijaykumar, Muniyappa and Punji, Benudhar}
}
@article {49411,
	title = {Palladium-catalyzed regioselective C(4)-H fluoroalkoxylation of indoles through weak chelation assistance},
	journal = {ChemCatChem},
	volume = {17},
	year = {2025},
	month = {JAN},
	type = {Article},
	abstract = {<p>
	Installing fluoroalkyl motifs into biorelevant indoles is particularly interesting due to their ubiquitous presence in drug molecules. Herein, we demonstrate the regioselective C4 fluoroalkoxylation of indoles using fluoroalcohols via palladium-catalyzed chelation-assisted C \&amp; horbar;H activation. The weak chelating benzoyl moiety at the C3 position acts as a directing group for remote C(4)\&amp; horbar;H fluoroalkoxylation of diversely substituted indoles. This methodology demonstrates a high level of regioselectivity and tolerates a range of crucial functional groups, yielding diverse trifluoroalkoxylated indoles in moderate to good yields. Removal of directing/protecting groups and further functionalization established the synthetic utility of the methodology. A preliminary mechanistic investigation is conducted by isolating the palladacycle intermediate and performing the deuterium scrambling study. The regioselective C4 fluoroalkoxylation of indoles with various fluoroalcohols is achieved by the palladium-catalyzed weak chelation assistance strategy. The reaction is compatible for a range of important functionalities and proceeds via the intermediacy of a six-membered palladacycle following a Pd(II)/Pd(IV) pathway. image</p>
},
	keywords = {C-H activation, indoles, Palladium, Regioselective, Trifluoroalkoxylation},
	issn = {1867-3880},
	doi = {10.1002/cctc.202401188},
	author = {Vijaykumar, Muniyappa and Gonnade, Rajesh G. and Punji, Benudhar}
}
