@article {49209,
	title = {Ru-catalyzed asymmetric transfer hydrogenation of racemic /3-keto γ-lactams via dynamic kinetic resolution},
	journal = {Tetrahedron},
	volume = {167},
	year = {2024},
	month = {NOV },
	pages = {134293},
	type = {Article},
	abstract = {<p>
	The enantioselective transfer hydrogenation of racemic /3-keto gamma-lactams via dynamic kinetic resolution using a chiral Ru(II) catalyst has been developed for the synthesis of optically active /3-hydroxyl lactams with excellent conversion (up to 99 \%), high diastereomeric ratio (dr dr 93:07) and enantiomeric selectivity (89 \% ee ). The reaction proceeded by using HCO2H/Et3N 2 H/Et 3 N as hydrogen donor and features mild, additive free reaction conditions, fast crystallization, broad substrate scope, and an operationally simpler setup than that for molecular hydrogenation.</p>
},
	keywords = {(R)-1-((R)-Pyrrolidin-3-yl)ethan-1-ol, /3-keto gamma-lactams, Asymmetric transfer hydrogenation, Dynamic kinetic resolution, Fluroquinolone antibiotics},
	issn = {0040-4020},
	doi = {10.1016/j.tet.2024.134293},
	author = {Malekar, V. Pushpa and More, V. Ganesh and Ramana, V. Chepuri}
}
