@article {48172,
	title = {Bioinspired hyaluronic acid based nanofibers immobilized with 3, 4-difluorobenzylidene curcumin for treating bacterial infections},
	journal = {Journal of Drug Delivery Science and Technology},
	volume = {74},
	year = {2022},
	month = {AUG},
	pages = {103480},
	type = {Article},
	abstract = {<p>
	Curcumin (Cur) is a natural polyphenol with multifaceted pharmacological functions, exploited extensively for biomedical applications. Traditionally curcumin is being used as an antimicrobial agent. However, to improvise the pharmacological properties, it is being modified synthetically. One of such modified Cur is 3, 4- difluorobenzylidene curcumin (CDF) which is aimed for enhancing the anti-cancer properties. Though there are reports on the studies of anti-cancer properties involving CDF, the anti-bacterial property is yet to be demonstrated. Accordingly, in our studies, we prepared bioinspired hyaluronic acid blends immobilized with CDF and fabricated non-woven nanofiber mats. These nanofiber mats were characterized and demonstrated in vitro cell culture studies, which involved cell viability, hemolysis, anti-bacterial and cell scratch assay to understand their efficacy in treating bacteria. The molecular docking studies of CDF and Cur were performed on the dihydrofolate reductase (DHFR) enzyme receptor, which is an essential protein of S.auerus (Staphylococcus aureus). The results of MTT (3-(4,5-Dimethylthiazol-2-yl)-2,5-Diphenyltetrazolium Bromide) assay, and hemolysis of the respective nanofiber mats with Cur and CDF showed non-toxicity and were compatible with blood cells. Further, the cell proliferation and adherence recorded \&gt;60\% fibroblast cells for the nanofiber mats. The anti-bacterial property of Cur and CDF was similar. The in vitro release studies for the respective Cur and CDF loaded nanofiber mats recorded a release of 25 and 37\%, respectively. From these studies, we concluded that the CDF sustained its antibacterial property in addition to the improved anti-cancer property; hence CDF being synergetic, it will have a better scope in cancer therapy.</p>
},
	keywords = {anti-bacterial, curcumin, nanofibers, tissue engineering, wound Healing},
	issn = {1773-2247},
	doi = {10.1016/j.jddst.2022.103480},
	author = {Patel, Pratikshkumar R. and Singam, Amarnath and Iyer, Arun K. and Gundloori, Rathna Venkata Naga}
}
@article {49956,
	title = {Stimulant immobilized bioactive film of functionalized egg albumin blend for wound healing},
	journal = {International Journal of Pharmaceutics},
	volume = {682},
	year = {2025},
	month = {SEP },
	pages = {125896},
	type = {Article},
	abstract = {<p>
	Wound healing materials with advanced properties that facilitates higher collagen deposition, improved angiogenesis and quick tissue regeneration are crucial for clinical wound management. To meet the requirement, for the first time, our studies focus on engineering bio-originated natural materials, which are tested in combination with the active agents, ascorbic acid (AA), a stimulant and metronidazole (Mtz), an anti-microbial drug. Accordingly, a dual drug (AA, and Mtz) loaded film of functionalized egg albumin (FEA)-poly(vinyl alcohol) (PVA) was fabricated following the solution casting method. The film was characterized for its morphology and physicochemical properties using various analytical tools. The potential of the film as a wound healing material was evaluated, by in vitro drug release, degradation, cell viability, antimicrobial studies, in vivo wound healing, and histopathological analyses. In vitro degradation studies confirmed their degradability in enzymatic and soil burial conditions. Cytotoxicity studies demonstrated their non-toxicity, and the antimicrobial investigations showcased that the material was antibacterial. On the 14th day, the wound closure percentage of the wound induced control group, GI (without treatment) was notably higher at 95 \% compared to the test formulation group, GV [FEA-PVA (30/70 w/w) loaded with Mtz and AA (10 \% w/w of the total polymer weight), respectively], which exhibited a wound closure of 83 \%. Furthermore, the histopathological examinations revealed that the inner wound healing in GV was comparatively better than in GI in terms of angiogenesis, epidermal remodeling, higher collagen deposition, coherency, and tissue regeneration. Consequently, the formulated film can be deemed a suitable wound dressing material.</p>
},
	keywords = {collagen, Dual drug release, Functionalized egg albumin, Polymer blend films, Stimulant, wound Healing},
	issn = {0378-5173},
	doi = {10.1016/j.ijpharm.2025.125896},
	author = {Gautam, Tripurari Rao and Patel, Pratikshkumar R. and Singam, Amarnath R. and Jagtap, Ashish S. and Desai, Prasad and Gundloori, Rathna V. N. and Pawar, Anil and Dastager, Syed G.}
}
