@article {46016,
	title = {Thiazolyl-pyrazole derivatives as potential antimycobacterial agents},
	journal = {Bioorganic \& Medicinal Chemistry Letters},
	volume = {29},
	year = {2019},
	month = {MAY},
	pages = {1199-1202},
	type = {Article},
	abstract = {<p>Mycobacterium tuberculosis (Mtb) is an obligate aerobe that is capable of long-term persistence under conditions of low oxygen tension. A series of thiazolyl-pyrazole derivatives (6a-f, 7a-f, 8c, 8e) were screened for antimycobacterial activity against dormant M. tuberculosis H37Ra (D-MTB) and M. bovis BCG (D-BCG). Nine thiazolyl- pyrazole analogs, 6c, 6e, 7a, 7b, 7c, 7e, 7f, 8c and 8e exhibited promissing minimum inhibitory concentration (MIC) values (0.20-28.25 mu g/mL) against D-MTB and D-BCG strains of Mtb. Importantly, six compounds (7a, 7b, 7e, 7f, 8c and 8e) exhibited excellent antimycobacterial activity and low cytotoxicity at the maximum evaluated concentration of \&gt; 250 mu g/mL. Finally, the promising antimycobacterial activity and lower cytotoxicity profile suggested that, these compounds could be further subjected for optimization and development as a lead, which could have the potential to treat tuberculosis.</p>},
	keywords = {antimycobacterial activity, Cytotoxicity, Pyrazole, thiazoles},
	issn = {0960-894X},
	doi = {10.1016/j.bmcl.2019.03.020},
	author = {Takate, Sushma J. and Shinde, Abhijit D. and Karale, Bhausaheb K. and Akolkar, Hemant and Nawale, Laxman and Sarkar, Dhiman and Mhaske, Pravin C.}
}
