@article {42435, title = {Unimolecular antiparallel G-quadruplex folding topology of 2{\textquoteright}-5{\textquoteright}-isoTBA sequences remains unaltered by loop composition}, journal = {Organic \& Biomolecular Chemistry}, volume = {13}, year = {2015}, month = {OCT}, pages = {11696-11703}, type = {Journal Article}, abstract = {

A 2{\textquoteright}-5{\textquoteright}-linked isoTBA 15 mer sequence with (232) loop composition formed stable antiparallel quadruplex structures similar to the SELEX derived 15 mer TBA sequence with (232) loop composition. A parallel versus antiparallel topology of 3{\textquoteright}-5{\textquoteright}-G-quadruplexes is largely dictated by the loop length, and it is known that the truncated loops favour parallel quadruplexes. In contrast to TBA, systematic reduction of the loop length in isoTBA from (232) to (222), (131) or even (111) did not alter the antiparallel topology of the resulting 14 mer, 13 mer and 11 mer G-rich modified isoTBA-like sequences.

}, doi = {10.1039/c5ob01923k}, author = {Aher, Manisha N.}, editor = {Erande, Namrata D.} } @article {48269, title = {Unlike RNA-TBA (rTBA), iso-rTBA, the 2 {\textquoteleft}-5 {\textquoteleft}-linked RNA-thrombin-binding aptamer, is a functional equivalent of TBA}, journal = {Chemical Communications}, volume = {59}, year = {2023}, month = {FEB}, pages = {1461-1464}, type = {Article}, abstract = {

An antiparallel, functional RNA G-quadruplex of the 2 {\textquoteleft}-5 {\textquoteleft}-linked thrombin-binding aptamer (iso-rTBA) is reported for the first time. It can inhibit clotting and is remarkably stable to nuclease-degradation, besides having high thermal stability. It is thus, a superior candidate to TBA, rTBA or isoTBA, for further development as an anticoagulant.

}, issn = {1359-7345}, doi = {10.1039/d2cc05718b}, author = {Wagh, Atish A. A. and Kumar, Vaijayanti A. A. and Ravindranathan, Sapna and Fernandes, Moneesha} }