@article {45366,
	title = {Synthesis and anticancer activity of conformationally constrained Smac mimetics containing pseudo beta turns},
	journal = {Tetrahedron Letters },
	volume = {59},
	year = {2018},
	month = {SEP},
	pages = {3473-3476},
	type = {Article},
	abstract = {Herein, we report synthesis and in vitro anticancer activity of conformationally constrained Smac mimetics containing reverse turn inducing motifs "Ant-Pro" and "sAnt-Pro". The synthesis of Smac analogs with diverse hydrophobic groups at the C-terminus was carried out using solution phase peptide synthesis. The synthesis of Ant-Pro containing analogs 3a-j was carried out by ring opening of benzoxazinones 7a-c, whereas, their sulfonamide counterparts 4a-h were synthesized by using routine acid-amine coupling reaction. In vitro anticancer studies against breast cancer cell line MDA-MB-231 revealed that some of the new analogs had better anticancer activity than the standard AVPI Smac tetrapeptide. (C) 2018 Published by Elsevier Ltd.},
	doi = {10.1016/j.tetlet.2018.08.016},
	author = {Baravkar, Sachin B. and Wagh, Mahendra A. and Paul, Debasish and Santra, Manas and Sanjayan, Gangadhar J.}
}
@article {49941,
	title = {Repurposed ciprofloxacin derivatives as potent autophagic-type anticancer agents},
	journal = {Bioorganic \& Medicinal Chemistry Letters},
	volume = {130},
	year = {2026},
	month = {JAN },
	pages = {130432},
	type = {Article},
	abstract = {<p>
	Drug repurposing - also known as drug repositioning is a proven strategy for identifying new therapeutic uses for existing and pre-approved drugs with considerable success in recent years. Herein, we report the discovery of a novel class of ciprofloxacin-amino acid conjugates that are dynamically potent against different cancer cell lines. Some of the molecules reported herein displayed a strong anti-proliferative effect on MCF-7 (IC50: 6 mu M). The most active anti-proliferative molecule of this series 7a suppressed the proliferation of HCT116, A549, and MDAMB-231 cancer cell lines. Furthermore, we established that the treatment with 7a leads to DNA damage-mediated autophagic cell death in cancer cells. Our findings suggest that appropriate derivatization of the ciprofloxacin drug can yield promising anti-cancer compounds in easy synthetic operations.</p>
},
	keywords = {Anticancer drugs, Autophagic cell death, ciprofloxacin},
	issn = {0960-894X},
	doi = {10.1016/j.bmcl.2025.130432},
	author = {Gone, Nilu Vijay and Sharma, Tanisha and Joshi, Rakesh and Upreti, Akshita and Santra, Manas and Sanjayan, Gangadhar J.}
}
