@article {49127,
	title = {Inhibitory effect of curcumin-artemisinin co-amorphous on Tau aggregation and Tau phosphorylation},
	journal = {Colloid and Surfaces B-Biointerfaces},
	volume = {221},
	year = {2023},
	month = {JAN},
	type = {Article},
	abstract = {<p>
	Tau is a natively unfolded microtubule-associated protein. Tau neurofibrillary tangles are one of the hallmarks of Alzheimer{\textquoteright}s disease. The post-translational modifications of Tau lead to its pathological state. Phosphorylation is the key post-translational modification associated with Tauopathy. Curcumin is a polyphenolic compound pre-sent in the rhizomes of Curcuma longa. Curcumin has been reported to have remarkable medicinal properties in several diseases, but its poor solubility limits its therapeutic potency. Artemisinin is a sesquiterpene lactone, which has been known sience ancient times for its applications as a treatment for various diseases such as malaria, cancer, autoimmune disease, etc. In the present study, the potency of crystalline curcumin, crystalline artemisinin, and Cur-Art co-amorphous dispersion were evaluated against Tau pathology. The in-vitro ThS/ANS fluorescence and electron microscopy results suggested that curcumin and Cur-Art efficiently inhibited Tau aggregation. Furthermore, exposure to curcumin and Cur-Art co-amorphous restored the impaired nuclear transport in formaldehyde-stressed cells. Curcumin was also found to modulate the phosphorylation of Tau, which indicated the neuroprotective potency. Thus, curcumin and Cur-Art co-amorphous exhibit therapeutic potential against Tau protein in Alzheimer{\textquoteright}s disease.</p>
},
	keywords = {artemisinin, curcumin, Phosphorylation, Tau Aggregation},
	issn = {0927-7765},
	doi = {10.1016/j.colsurfb.2022.112970},
	author = {Dubey, Tushar and Sonawane, Shweta Kishor and Mannava, M. K. Chaitanya and Nangia, Ashwini K. and Chandrashekar, Madhura and Chinnathambi, Subashchandrabose}
}
