@article {46163,
	title = {Scalable synthesis of cladosporin},
	journal = {Tetrahedron Letters},
	volume = {60},
	year = {2019},
	month = {MAR },
	pages = {831-833},
	type = {Article},
	abstract = {<p>Cladosporin, a secondary metabolite isolated from fungal sources like Cladosporium cladosporioides and Aspergillus flavus was found to exhibit selective nano-molar activity against malarial parasite Plasmodium falciparum by inhibiting parasitic protein biosynthesis. In addition, this natural product has a broad range of bioactivities including, antiparasitic, antifungal, antibacterial as well as plant growth inhibition. However, it has limited availability from the natural sources for further development. Herein, we report a modified and improved synthetic route which led us to produce this potent natural product in a gram scale. Conversion of the undesired diastereomer to desired one via Mitsunobu inversion of secondary alcohol and carbon monoxide insertion reaction towards the construction of isocoumarin unit are the key features of the present synthesis. (C) 2019 Elsevier Ltd. All rights reserved.</p>
},
	keywords = {Anti-malarials, Cladosporin, Mitsunobu, Total synthesis},
	issn = {0040-4039},
	doi = {10.1016/j.tetlet.2019.02.012},
	author = {Das, Pronay and Mankad, Yash and Reddy, D. Srinivasa}
}
@article {47402,
	title = {Total synthesis of twelve membered resorcyclic acid lactones, (R)-penicimenolide A, (R)-resorcyclide and (R)-dihydroresorcyclide},
	journal = {Tetrahedron},
	volume = {85},
	year = {2021},
	month = {APR},
	pages = {132059},
	type = {Article},
	abstract = {<p>Resorcyclic Acid Lactones or RALs are a class of fungal secondary polyketides isolated from a variety of fungal strains like Lasiodiplodia theobromae, Penicillium sp., Syncephalastrum racemosum etc. This class of macrocyclic lactones are found to exhibit a broad spectrum of biological activities and are of significant synthetic importance. Herein, we report the first total synthesis of (R)-penicimenolide A, twelve membered RAL (RAL12) isolated from Penicillium sp. (NO. SYP-F-7919). Besides, we also report the total synthesis of two other members, namely, (R)-trans-resorcyclide and (R)-dihydroresorcyclide. In the course of synthesis, we have utilized ring closing metathesis (RCM) as the key step in constructing the core macrolactone scaffold. (C) 2021 Elsevier Ltd. All rights reserved.</p>},
	keywords = {Macrocycle, Natural product, organic synthesis, Total synthesis},
	issn = {0040-4020},
	doi = {10.1016/j.tet.2021.132059},
	author = {Das, Pronay and Reddy, D. Srinivasa}
}
