@article {44604,
	title = {Supramolecular reassembly of self-exfoliated ionic covalent organic nanosheets for label-free detection of double-stranded DNA},
	journal = {Angewandte Chemie-International Edition},
	volume = {57},
	year = {2018},
	month = {JUL },
	pages = {8443-8447},
	abstract = {<p>Ionic covalent organic nanosheets (iCONs), a member of the two-dimensional (2D) nanomaterials family, offer a unique functional platform for a wide range of applications. Herein, we explore the potential of an ethidium bromide (EB)-based covalent organic framework (EB-TFP) that self-exfoliates in water resulting in 2D ionic covalent organic nanosheets (EB-TFP-iCONs) for the selective detection of double-stranded DNA (dsDNA). In an aqueous medium, the self-exfoliated EB-TFP-iCONs reassemble in the presence of dsDNA resulting in hybrid EB-TFP-iCONs-DNA crystalline nanosheets with enhanced fluorescence at 600 nm. Detailed steady-state and time-resolved emission studies revealed that the reassembly phenomenon was highly selective for dsDNA when compared to single-stranded DNA (ssDNA), which allowed us to use the EB-TFP-iCONs as a 2D fluorescent platform for the label-free detection of complementary DNA strands.</p>},
	keywords = {Covalent organic framework, DNA, ionic assembly, ionic covalent organic nanosheets, label-free detection},
	issn = {1433-7851},
	doi = {10.1002/anie.201801352},
	author = {Mal, Arindam and Mishra, Rakesh K. and Praveen, Vakayil K. and Khayum, M. Abdul and Banerjee, Rahul and Ajayaghosh, Ayyappanpillai}
}
