@article {44514,
	title = {Lipase catalyzed synthesis of antimicrobial andrographolide derivatives},
	journal = {Data in Brief},
	volume = {18},
	year = {2018},
	month = {JUN},
	pages = {1134-1141},
	abstract = {In this data article we describe screening of various lipases for the regioselective acylation of Andrographolide. Each lipase was screened with seven acyl donors. Amano lipase AK from Pseudomonas fluorescens was used for the synthesis of two new acylated andrographolide derivatives. Two new compounds, andrographolide-14-propionate and andrographolide-14-caproate were characterized by various spectral studies. These two derivatives showed more antimicrobial activity than andrographolide.},
	doi = {10.1016/j.dib.2018.03.103},
	author = {Patil, Harshal S. and Jadhav, Dipesh and Paul, Ajay and Mulani, Fayaj Alam and Karegaonkar, Shrikant J. and Thulasiram, Hirekodathakallu V.}
}
@article {47776,
	title = {Neem derivatives inhibits tau aggregation},
	journal = {Journal of Alzheimer s Disease Reports},
	volume = {3},
	year = {2021},
	month = {JAN},
	pages = {169-178},
	type = {Article},
	abstract = {Tau is a phosphoprotein with natively unfolded conformation that functions to stabilize microtubules in axons. Alzheimer{\textquoteright}s disease pathology triggers several modifications in tau, which causes it to lose its affinity towards microtubule, thus, leading to microtubule disassembly and loss of axonal integrity. This elicit accumulation of tau as paired helical filaments is followed by stable neurofibrillary tangles formation. A large number of small molecules have been isolated from Azadirachta indica with varied medicinal applications. The intermediate and final limonoids, nimbin and salannin respectively, isolated from Azadirachta indica, were screened against tau aggregation. ThS and ANS fluorescence assay showed the role of intermediate and final limonoids in preventing heparin induced cross-β sheet formation and also decreased hydrophobicity, which are characteristic nature of tau aggregation. Transmission electron microscopy studies revealed that limonoids restricted the aggregation of tau to fibrils; in turn, limonoids led to the formation of short and fragile aggregates. Both the limonoids were non-toxic to HEK293T cells thus, substantiating limonoids as a potential lead in overcoming Alzheimer{\textquoteright}s disease.},
	doi = {10.3233/ADR-190118},
	author = {Nalini, Gorantla Vijay and Das, Rashmi and Mulani, Fayaj Alam and Thulasiram, Hirekodathakallu V. and Chinnathambi, Subashchandrabose}
}
