@article {44455,
	title = {Tris-hydroxymethylaminomethane (THAM): An efficient organocatalyst in diversity-oriented and environmentally benign synthesis of spirochromenes},
	journal = {Comptes Rendus Chimie},
	volume = {21},
	year = {2018},
	month = {JUN },
	pages = {814-821},
	type = {Article},
	abstract = {<p>Tris-hydroxymethylaminomethane has been demonstrated to be an efficient organocatalyst in diversity-oriented synthesis of medicinally prevalent spirochromenes by one-pot, three-component reactions between isatins, malononitrile, and enolizable CH acids like dimedone, 4-hydroxycoumarin, 4-hydroxy-N-methylquinolin-2-one, or in situ generated 2-methylpyrazolon-2-one. Biodegradability and extremely low cost of the catalyst are the noteworthy features of this chromatography-free protocol.</p>},
	keywords = {green chemistry, Multicomponent synthesis, organocatalysis, Spirochromenes, Tris-hydroxymethylaminomethane},
	issn = {16310748},
	doi = {10.1016/j.crci.2018.05.005},
	author = {Khot, Supriya S. and Anbhule, Prashant V. and Desai, Uday V. and Wadgaonkar, Prakash P.}
}
