@article {44357,
	title = {Favorable 2 {\textquoteright}-substitution in the loop region of a thrombin-binding DNA aptamer},
	journal = {Bioorganic \& Medicinal Chemistry Letters},
	volume = {28},
	year = {2018},
	month = {JUN},
	pages = {1765-1768},
	type = {Article},
	abstract = {Simple 2{\textquoteright}-OMe-chemical modification in the loop region of the 15mer G-rich DNA sequence GGTTGGTGTGGTTGG is reported. The G-quadruplex structure of this thrombin-binding aptamer (TBA), is stabilized by single modifications (T -> 2{\textquoteright}-OMe-U), depending on the position of the modification. The structural stability also renders significantly increased inhibition of thrombin-induced fibrin polymerization, a process closely associated with blood-clotting. (C) 2018 Elsevier Ltd. All rights reserved.},
	doi = {10.1016/j.bmcl.2018.04.027},
	author = {Awachat, Ragini and Wagh, Atish A. and Aher, Manisha and Fernandes, Moneesha and Kumar, Vaijayanti A.}
}
