@article { ISI:000340469800024,
	title = {Highly efficient chiral resolution of DL-arginine by cocrystal formation followed by recrystallization under preferential-enrichment conditions},
	journal = {Chemistry-A European Journal},
	volume = {20},
	number = {33},
	year = {2014},
	month = {AUG},
	pages = {10343-10350},
	publisher = {WILEY-V C H VERLAG GMBH},
	address = {BOSCHSTRASSE 12, D-69469 WEINHEIM, GERMANY},
	abstract = {<p>An excellent chiral symmetry-breaking spontaneous enantiomeric resolution phenomenon, denoted preferential enrichment, was observed on recrystallization of the 1:1 cocrystal of dl-arginine and fumaric acid, which is classified as a racemic compound crystal with a high eutectic ee value (\&gt;95\%), under non-equilibrium crystallization conditions. On the basis of temperature-controlled video microscopy and in situ time-resolved solid-state (CNMR)-C-13 spectroscopic studies on the crystallization process, a new mechanism of phase transition that can induce preferential enrichment is proposed.</p>},
	keywords = {Amino acids, chiral resolution, cocrystals, Crystal growth, phase transitions},
	issn = {0947-6539},
	doi = {10.1002/chem.201402446},
	author = {Iwama, Sekai and Kuyama, Kazunori and Mori, Yuko and Manoj, Kochunnoonny and Gonnade, Rajesh G. and Suzuki, Katsuaki and Hughes, Colan E. and Williams, P. Andrew and Harris, Kenneth D. M. and Veesler, Stephane and Takahashi, Hiroki and Tsue, Hirohito and Tamura, Rui}
}
@article { ISI:000356370500002,
	title = {Preferential enrichment of DL-leucine using cocrystal formation with oxalic acid under nonequilibrium crystallization conditions},
	journal = {Chirality},
	volume = {27},
	number = {7},
	year = {2015},
	month = {JUL},
	pages = {405-410},
	publisher = {WILEY-BLACKWELL},
	address = {111 RIVER ST, HOBOKEN 07030-5774, NJ USA},
	abstract = {<p>By utilizing the preferential enrichment (PE) technique, we achieved an improved enantiomeric resolution of DL-leucine (Leu) using a 1:1 cocrystal (DL-1) of DL-Leu and oxalic acid. The crystal structure analysis of DL-1 indicated the occurrence of a novel type of phase transition and subsequent preferential redissolution of one enantiomer from the resulting crystals into solution. Chirality 27:405-410 2015. (c) 2015 Wiley Periodicals, Inc.</p>},
	keywords = {chiral resolution, cocrystal formation, leucine, phase transition, preferential enrichment},
	issn = {0899-0042},
	doi = {10.1002/chir.22431},
	author = {Manoj, Kochunnoonny and Takahashi, Hiroki and Morita, Yoko and Gonnade, Rajesh G. and Iwama, Sekai and Tsue, Hirohito and Tamura, Rui}
}
