@article { ISI:000357468200016,
	title = {Discovery of rimonabant and its potential analogues as anti-TB drug candidates},
	journal = {Medicinal Chemistry Research},
	volume = {24},
	number = {7},
	year = {2015},
	month = {JUL},
	pages = {2960-2971},
	publisher = {SPRINGER BIRKHAUSER},
	address = {233 SPRING STREET, 6TH FLOOR, NEW YORK, NY 10013 USA},
	abstract = {<p>Rimonabant and its analogues have been synthesized in moderate to good yields using a simple synthetic route. All the newly synthesized compounds were subjected to in vitro screening against M. tuberculosis and M. smegmatis. The most potent analogue JMG-14 exhibits MIC value of 3.13 compared to 3.25 and 50 A mu g/ml for ethambutol and pyrazinamide, respectively. The molecular docking reveals that pyrazole ring, number and position of halogen atoms play a crucial role in deciding interactions with MTCYP-121. These findings open up a new avenue in the search of potent anti-TB drugs with rimonabant and its novel analogue JMG-14 as lead molecules.</p>},
	keywords = {Diaryl pyrazoles, H37Rv, MTCYP-121, Mycobacterium tuberculosis, Rimonabant, tuberculosis},
	issn = {1054-2523},
	doi = {10.1007/s00044-015-1346-4},
	author = {Gajbhiye, J. M. and More, Namita A. and Patil, Manoj D. and Ummanni, R. and Kotapalli, S. S. and Yogeeswari, P. and Sriram, D. and Masand, Vijay H.}
}
@article { ISI:000374876700814,
	title = {Repurposing of old drugs: identification of novel sila analogues of rimonabant as potent antitubercular agents},
	journal = {International Journal of Infectious Diseases},
	volume = {45},
	number = {1},
	year = {2016},
	month = {APR},
	pages = {407-408},
	publisher = {ELSEVIER SCI LTD},
	address = {THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND},
	issn = {1201-9712},
	doi = {10.1016/j.ijid.2016.02.870},
	author = {Ramesh, R. and Shingare, R. and Anand, Amitesh and Veeraraghavan, S. and Viswanadha, S. and Ummanni, R. and Gokhale, R. and Reddy, D. S.}
}
