@article {46995,
	title = {Highly enantioselective synthesis of sitagliptin},
	journal = {Asian Journal of Organic Chemistry},
	volume = {9},
	year = {2020},
	month = {FEB},
	pages = {189-191},
	type = {Article},
	abstract = {<p>A highly enantioselective synthesis of sitagliptin, a potent DPP-4 inhibitor, is reported. Explicitly identified chiral FerroLANE ligands in the presence of rhodium catalyze the asymmetric hydrogenation of an enamine to yield sitagliptin with excellent enantioselectivity (98\% ee). The process was scaled up to 5 g and the final product was isolated as a phosphate salt with \&gt;99\% ee.</p>
},
	keywords = {asymmetric hydrogenation, catalysis, FerroLANE ligands, Rhodium, sitagliptin},
	issn = {2193-5807},
	doi = {10.1002/ajoc.201900709, Early Access Date = JAN 2020},
	author = {Khopade, V. Kishor and Sen, Anirban and Birajdar, Rajkumar S. and Paulbudhe, Uday P. and Kavale, Dattatry S. and Shinde, Prashant S. and Mhaske, Santosh B. and Chikkali, Samir H.}
}
@article {47899,
	title = {Mechanistically guided one pot synthesis of phosphine-phosphite and its implication in asymmetric hydrogenation},
	journal = {European Journal of Organic Chemistry},
	volume = {2022},
	year = {2022},
	month = {JAN},
	pages = {e202101447},
	type = {Article},
	abstract = {<p>
	Although hybrid bidentate ligands are known to yield highly enantioselective products in asymmetric hydrogenation (AH), synthesis of these ligands is an arduous process. Herein, a one pot, atom-economic synthesis of a hybrid phosphine-phosphite (L1) is reported. After understanding the reactivity difference between an 0-nucleophile versus C-nucleophile, one pot synthesis of Senphos (L1) was achieved (72\%). When L1 was treated with [Rh], P-31 NMR revealed bidentate coordination to Rh. Senphos, in the presence of rhodium, catalyzes the AH of Methyl-2-acetamido-3-phenylacrylate and discloses an unprecedented turn over frequency of 2289, along with excellent enantio-selectivity (92\%). The generality is demonstrated by hydrogenating an array of alkenes. The AH operates under mild conditions of 1-2 bar H-2 pressure, at room temperature. The practical relevance of Ll is demonstrated by scaling-up the reaction to 1 g and by synthesizing DOPA, a drug widely employed for the treatment of Parkinson{\textquoteright}s disease. Computational insights indicate that the R isomer is preferred by 3.8 kcal/mol over the S isomer.</p>
},
	keywords = {asymmetric hydrogenation, catalysis, DOPA synthesis, One pot synthesis, Phosphine-phosphite ligand},
	issn = {1434-193X},
	doi = {10.1002/ejoc.202101447},
	author = {Sen, Anirban and Kumar, Rohit and Pandey, Swechchha and Raj, K. Vipin and Kumar, Pawan and Vanka, Kumar and Chikkali, Samir H.}
}
