@article { ISI:000312003800010,
	title = {Synthetic studies towards NG-121: diastereoselective synthesis of NG-121 methyl ether},
	journal = {Synthesis-Stuttgart},
	volume = {44},
	number = {24},
	year = {2012},
	month = {DEC},
	pages = {3797-3804},
	publisher = {GEORG THIEME VERLAG KG},
	address = {RUDIGERSTR 14, D-70469 STUTTGART, GERMANY},
	abstract = {<p>Starting from unsymmetrically O-protected methyl 4-bromo-3,5-dihydroxybenzoate, a facile synthesis of the methyl ether of bioactive natural product NG-121 was accomplished in very good overall yield. The key steps were: Stille coupling reaction of the farnesyl unit with the electron-rich phenolic segment; hydroxy-directed selective epoxidation of the farnesyl chain along with concomitant phenol-driven intramolecular regio- and diastereoselective ring closure to the corresponding hydroxybenzopyran; and regioselective formylation followed by in situ reductive lactonization.</p>},
	keywords = {4-bromo-3, 5-dihydroxybenzoate, formylation, intramolecular cyclization, lactonization, NG-121 methyl ether, Stille coupling},
	issn = {0039-7881},
	doi = {10.1055/s-0032-1317544},
	author = {Singh, Mandeep and N. P. Argade}
}
