@article {45926,
	title = {Potential applications of glucosyltransferases in terpene glucoside production: impacts on the use of aroma and fragrance},
	journal = {Applied Microbiology and Biotechnology},
	volume = {99},
	year = {2015},
	month = {JAN},
	pages = {165-174},
	type = {Article},
	abstract = {<p>The detection of glucoconjugated forms of monoterpene alcohols in rose petals in the late 1960s opened the new field of nonvolatile aroma precursors in flavor research. It is now well established that odorless glycosides represent a significant pool of aroma precursors in plants where they act as preformed but inactivated defense or attractive chemicals. Technical improvements in the separation and identification of plant secondary metabolites have provided a multitude of chemical structures, but functional characterization of glycosyltransferases that catalyze their formation lags behind. As technical efforts and costs for DNA sequencing dramatically dropped during the last decade, the number of plant genome sequences increased significantly, thus providing opportunities to functionally characterize the glycosyltransferase gene families in plants. These studies yielded the first glycosyltransferase genes that encode efficient biocatalysts for the production of monoterpene glucosides. They have applications in the food, feed, chemical, cosmetic, and pharmaceutical industries as slow release aroma chemicals.</p>},
	issn = {0175-7598},
	doi = {10.1007/s00253-014-6229-y},
	author = {Schwab, Wilfried and Fischer, Thilo C. and Giri, Ashok and Wuest, Matthias}
}
@article {50037,
	title = {Phenylpropanoid-specific glycosyltransferases from mango and their potential role in defense},
	journal = {Plant Physiology and Biochemistry},
	volume = {232},
	year = {2026},
	month = {MAR},
	pages = {111137},
	type = {Article},
	abstract = {<p>
	Alphonso mango (Mangifera indica cv. Alphonso) is a cornerstone of India{\textquoteright}s fruit industry due to its distinct aroma and shelf-life characteristics. The uridine diphosphate-dependent glycosyltransferases (UGTs) play a crucial role in stabilising aroma and defense-related specialised metabolites in fruits. The present study explores the potential role of UGTs during mango ripening and Colletotrichum gloeosporioides infection. Gene expression analysis indicated that UGTs showed dynamic expression in skin and pulp during ripening. Phylogenetic analysis revealed substrate-driven divergence of UGTs, with MiUGT92A14 and MiUGT95B15 forming distinct clades associated with flavonoid glycosylation. Recombinant UGTs showed a higher preference for UDP-glucose, which is corroborated by the high accumulation of UDP-glucose during ripening. Furthermore, it was observed that MiUGT92A14 prefers phenolic acids as substrates, while MiGT95B15 shows flavonoid specificity. Spore germination assays demonstrated that both aglycones and their glycosylated derivatives suppressed early fungal morphogenesis, supporting a role for UGT-mediated glycosylation in maintaining defense-related metabolites in a bioactive yet non-toxic form during fruit ripening. Additionally, Colletotrichum gloeosporioides inhibition assays demonstrated that glycosylated products of selected UGTs exhibited equal or enhanced antifungal activity compared with their aglycone forms, indicating that glycosylation promotes the safe accumulation of antifungal compounds by reducing aglycone toxicity to the plant. These findings suggest that glycosylation of specific metabolites is a key for ripening process and to potentiate defence against fungal pathogen.</p>
},
	keywords = {Anthracnose, defense, Flavonoid, Glycoconjugates, Uridine diphosphate-dependent glycosyl-transferase},
	issn = {0981-9428},
	doi = {10.1016/j.plaphy.2026.111137},
	author = {Vare, Tejas and Joshi, Rakesh and Liao, Jieren and Hoffmann, Thomas and Schwab, Wilfried and Giri, Ashok}
}
