@article {48726,
	title = {C-H functionalization of pyridines},
	journal = {Organic \& Biomolecular Chemistry},
	volume = {21},
	year = {2023},
	month = {JUL},
	pages = {5671-5690},
	type = {Review},
	abstract = {<p>
	Pyridine and its reduced form (piperidine) are the most common nitrogen heterocycles in FDA-approved drugs. Additionally, their presence in alkaloids, ligands for transition metals, catalysts, and organic materials with various properties makes them among the most important structural cores. Despite its importance, direct and selective functionalization of pyridine remains scarce due to its electron-poor nature and nitrogen coordination power. Instead, functionalized pyridine rings were primarily constructed from suitably substituted acyclic precursors. The focus on sustainable chemistry with minimum waste generation encourages chemists to develop direct C-H functionalization. This review summarizes different approaches to tackle the reactivity and regio- and stereoselectivity aspects for direct pyridine C-H functionalization.</p>
},
	issn = {1477-0520},
	doi = {10.1039/d3ob00799e},
	author = {Maity, Susmita and Bera, Asish and Bhattacharjya, Ayantika and Maity, Pradip}
}
@article {48316,
	title = {Controlled synthesis of thermosensitive tunable porous film of (pNIPAM)-b-(PCL) copolymer for sustain drug delivery},
	journal = {Journal of Applied Polymer Science},
	volume = {140},
	year = {2023},
	month = {MAY},
	pages = {e53854},
	type = {Article},
	abstract = {<p>
	There have been reports on different types of porous polymer films for various applications. The designing of such porous films with uniform properties is a challenging task. In this work, tunable porous thin films of poly(N-isopropylacrylamide) (pNIPAM) and polycaprolactone (PCL), that is, (pNIPAM)-b-(PCL) has been fabricated and its sustained drug delivery applications have been reported. First, the (pNIPAM)-b-(PCL) has been synthesized through the addition polymerization of pNIPAM and PCL. Then the synthesized (pNIPAM)-b(PCL) has been used to design porous thin film with varying temperatures without using any external template, below and above the lower critical solution temperatures (LCST) of pNIPAM. Pore size in (pNIPAM)-b-(PCL) films has been tuned by varying the temperature from similar to 10 to 40 degrees C. Then the developed thermosensitive porous film has been taken and seeded with the K562 (chronic myeloid leukemia blood cancer) and HepG2 (hepatocarcinoma) cells and the skin cancer cells (B16-F10) killing efficiency of anticancer drug (e.g., doxorubicin hydrochloride, DOX) loaded (pNIPAM)-b-(PCL) film has been studied. It is found that the DOX-loaded (pNIPAM)-b-(PCL) can efficiently kill the skin cancer cells. The porous polymer thin film reported in this work can be a versatile platform for the loading of drugs and it can be used for the various therapeutic applications.</p>
},
	keywords = {Biomaterials, Biomedical Applications, drug delivery systems, films, nanostructured polymers},
	issn = {0021-8995},
	doi = {10.1002/app.53854},
	author = {Amgoth, Chander and Patra, Sukanya and Wasnik, Kirti and Maity, Pradip and Paik, Pradip}
}
