@article {46337,
	title = {Allenoate prenucleophiles: a triply diastereoselective approach to beta-hydroxy esters containing all-carbon alpha-quaternary centers},
	journal = {Organic Letters},
	volume = {21},
	year = {2019},
	month = {OCT },
	pages = {7952-7955},
	type = {Article},
	abstract = {<p>Allenyl esters activated by titanium(IV) underwent additions to a wide range of aldehydes in high regio- and diastereoselectivities leading to products containing an all carbon quaternary center bearing an alpha-vinyl group that was installed with high selectivity for the Z-geometry. An aldol product was also converted to an indanone offering a new route to this important compound class. Product triple diastereoselectivity has been rationalized using a concerted transition-state model.</p>
},
	issn = {1523-7060},
	doi = {10.1021/acs.orglett.9b02930},
	author = {Maki, Samantha L. and Maity, Pradip and Dougherty, Shannon and Johns, Jennifer and Lepore, Salvatore D.}
}
@article {49912,
	title = {Anionic 5-endo-dig cyclizations: an experimental investigation of in-plane aromaticity involving a non-enolate carbanion nucleophile},
	journal = {Organic Chemistry Frontiers},
	volume = {12},
	year = {2025},
	month = {NOV},
	pages = {6609-6613},
	type = {Article},
	abstract = {<p>
	Cyclitive additions of aliphatic carbanions to non-electrophilic carbon-carbon triple bonds under mild, transition-metal-free conditions are described for the first time. These results confirm theoretical models that invoke in-plane aromaticity to predict the favorability of 5-endo-dig reactions in these systems. In contrast to related Conia-ene cyclizations (5-enolexo-endo-dig), our results generally led to cyclic and allene products in near parity ratios across a broad range of substrates, suggesting that cyclization may proceed via an early ambimodal transition state. Experimental results are presented with a view to refining existing mechanistic models for this growing class of alkyne reactions.</p>
},
	doi = {10.1039/d5qo00547g},
	author = {Nugent, Kristina M. and Hintze, Silas Q. and Maity, Pradip and Lepore, Salvatore D.}
}
