@article {46756,
	title = {Understanding fundamentals of hepatocellular carcinoma to design next-generation chitosan nano-formulations: Beyond chemotherapy stride},
	journal = {Journal of Drug Delivery Science and Technology},
	volume = {58},
	year = {2020},
	month = {AUG},
	pages = {101723},
	type = {Article},
	abstract = {<p>Hepatocellular carcinoma (HCC) is the deadliest form of liver cancer. Clinically, the main strategies currently being used for the treatment of HCC are surgery, radiotherapy and chemotherapy. Conventional chemotherapy has major drawbacks such as poor bioavailability, high-dose requirements, adverse side effects, low therapeutic indices, and non-specific drug targeting. Therefore, targeted drug delivery systems are fast becoming new tools for the selective killing of cancer cells. Chitosan (CS) is a biodegradable, biocompatible, cationic and natural biopolymer that also exhibits anti-cancer property which is now being explored as a promising candidate for targeted drug delivery. This review outlines an overview of the causative agents, microenvironment, pathophysiology, surface-biomarkers and physiological barriers of HCC. Then, the cellular internalization pathways of nanomedicine and the important physicochemical properties of delivery agents are discussed. The benefits of targeted therapy over conventional therapy with regard to HCC are also discussed. The main objective of this review was to summarize the current knowledge in the field of chitosan-based drug delivery for the management of HCC along with its limitations in a comprehensive and systematic way. This review attempts to provide a holistic roadmap for designing the next-generation chitosan-based drug delivery systems for HCC management.</p>
},
	keywords = {chitosan nanoparticles, Hepatocellular carcinoma, Pathophysiology, Surface biomarkers, Targeted Drug Delivery, Tumor microenvironment},
	issn = {1773-2247},
	doi = {10.1016/j.jddst.2020.101723},
	author = {Jaiswal, Neha and Chaudhari, Ravindra D. and Chaudhari, Bhushan P.}
}
@article {48318,
	title = {Challenges and emerging strategies for next generation liposomal based drug delivery: an account of the breast cancer conundrum},
	journal = {Chemistry and Physics of Lipids},
	volume = {250},
	year = {2023},
	month = {JAN},
	pages = {105258},
	type = {Article},
	abstract = {<p>
	The global cancer burden is witnessing an upsurge with breast cancer surpassing other cancers worldwide. Furthermore, an escalation in the breast cancer caseload is also expected in the coming years. The conventional therapeutic regimens practiced routinely are associated with many drawbacks to which nanotechnological in-terventions offer a great advantage. But how eminent could liposomes and their advantages be in superseding these existing therapeutic modalities? A solution is reflected in this review that draws attention to a decade-long journey embarked upon by researchers in this wake. This text is a comprehensive discussion of liposomes, the front runners of the drug delivery systems, and their active and passive targeting approaches for breast cancer management. Active targeting has been studied over the decade by many receptors overexpressed on the breast cancer cells and passive targeting with many drug combinations. The results converge on the fact that the actively targeted formulations exhibit a superior efficacy over their non-targeted counterparts and the all lipo-somal formulations are efficacious over the free drugs. This undoubtedly underlines the dominion of liposomal formulations over conventional chemotherapy. These investigations have led to the development of different liposomal formulations with active and passive targeting capacities that could be explored in depth. Acknowl-edging and getting a deeper insight into the liposomal evolution through time also unveiled many imperfections and unchartered territories that can be explored to deliver dexterous liposomal formulations against breast cancer and more in the clinical trial pipeline.</p>
},
	keywords = {Breast cancer, Liposomal metamorphosis, Receptor-ligand dynamics, Targeted Drug Delivery},
	issn = {0009-3084},
	doi = {10.1016/j.chemphyslip.2022.105258},
	author = {Moudgil, Aliesha and Salve, Rajesh and Gajbhiye, Virendra and Chaudhari, Bhushan P.}
}
