@article {43910,
	title = {Enantioselective synthesis of functionalized β-lactones by NHC-catalyzed aldol lactonization of ketoacids},
	journal = {Journal of Organic Chemistry},
	volume = {82},
	year = {2017},
	month = {AUG},
	type = {Article},
	abstract = {N-Heterocyclic carbene (NHC)-catalyzed intramolecular aldol lactonization of readily available ketoacids leading to the enantioselective synthesis of cyclopentane-fused β-lactones is presented. The reaction proceeds via the generation of NHC-bound enolate intermediates formed from the ketoacids in the presence of the peptide coupling reagent HATU and NHC generated from the chiral triazolium salt. The functionalized β-lactones are formed under mild conditions in high yields and enantioselectivities.},
	doi = {10.1021/acs.joc.7b01526},
	author = {Mondal, Santigopal and Mukherjee, Subrata and Das, Tamal Kanti and Gonnade, Rajesh G. and Biju, Akkattu T.}
}
