@article { ISI:000247546800001,
	title = {Modified nucleic acid substructures in medicinal chemistry and drug development},
	journal = {Current Topics in Medicinal Chemistry},
	volume = {7},
	number = {7},
	year = {2007},
	month = {JAN},
	pages = {639},
	publisher = {BENTHAM SCIENCE PUBL LTD},
	type = {Article},
	address = {EXECUTIVE STE Y26, PO BOX 7917, SAIF ZONE, 1200 BR SHARJAH, U ARAB EMIRATES},
	issn = {1568-0266},
	doi = {10.2174/156802607780487731},
	author = {Kumar, Vaijayanti A.}
}
@article {46999,
	title = {Methoxymethyl threofuranosyl thymidine (4 {\textquoteleft}-MOM-TNA-T) at the T7 position of the thrombin-binding aptamer boosts anticoagulation activity, thermal stability, and nuclease resistance},
	journal = {ACS Omega},
	volume = {5},
	year = {2020},
	month = {JAN },
	pages = {498-506},
	type = {Article},
	abstract = {<p>The synthesis of 4{\textquoteright}-methoxymethyl threofuranosyl (4{\textquoteright}-MOM-TNA) thymidine and derived oligomers of the G-rich thrombin-binding aptameric (TBA) sequence is reported. The G-quadruplex stability, anticoagulation activity, and the enzymatic stability of these oligomers bearing the 2{\textquoteright}-3{\textquoteright}-phosphodiester backbone as single substitutions in the loop regions are studied. Amongst all the oligomers, TBA-7T bearing the 4{\textquoteright}-MOM-TNA unit at the T7 position formed a quadruplex with the highest thermal stability. It also resulted in enhanced anticlotting activity that allowed a one-third reduction in the dose, relative to TBA. Further, TBA-7T exhibited enhanced nuclease resistance properties to both endo- and exonucleases.</p>
},
	issn = {2470-1343},
	doi = {10.1021/acsomega.9b03042},
	author = {Varada, Manojkumar and Aher, Manisha and Erande, Namrata and Kumar, Vaijayanti A. and Fernandes, Moneesha}
}
