@article { ISI:000252757100011, title = {Chimeric (alpha-amino acid plus nucleoside-beta-amino acid)(n) peptide oligomers show sequence specific DNA/RNA recognition}, journal = {Chemical Communications}, number = {6}, year = {2008}, month = {JAN}, pages = {706-708}, publisher = {ROYAL SOC CHEMISTRY}, type = {Article}, address = {THOMAS GRAHAM HOUSE, SCIENCE PARK, MILTON RD, CAMBRIDGE CB4 0WF, CAMBS, ENGLAND}, abstract = {

An alpha/beta-peptide backbone oligonucleotide comprising natural alpha-amino acids alternating with a beta-amino acid component derived from thymidine sequence specifically recognizes and binds to deoxy- and ribo-oligoadenylates in triplex mode.

}, issn = {1359-7345}, doi = {10.1039/b716835g}, author = {Gogoi, Khirud and Kumar, Vaijayanti A.} } @article { ISI:000207861902126, title = {CARB 36-Novel and structurally biased backbone modifications of nucleic acids}, journal = {Abstracts of Papers of the American Chemical Society}, volume = {238}, year = {2009}, month = {AUG}, pages = {Meeting Abstract : 36-CARB}, publisher = {AMER CHEMICAL SOC}, type = {Meeting Abstract}, address = {1155 16TH ST, NW, WASHINGTON, DC 20036 USA}, issn = {0065-7727}, author = {Kumar, Vaijayanti A.} } @article { ISI:000320838200014, title = {C-3 {\textquoteleft}-endo-puckered pyrrolidine containing PNA has favorable geometry for RNA binding: novel ethano locked PNA (ethano-PNA)}, journal = {Bioorganic \& Medicinal Chemistry}, volume = {21}, number = {14}, year = {2013}, month = {JUL}, pages = {4092-4101}, publisher = {PERGAMON-ELSEVIER SCIENCE LTD}, address = {THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND}, abstract = {

A novel peptide nucleic acid (PNA) analogue is designed with a constraint in the aminoethyl segment of the aegPNA backbone so that the dihedral angle beta is restricted within 60-80 degrees, compatible to form PNA:RNA duplexes. The designed monomer is further functionalized with positively charged amino-/guanidino-groups. The appropriately protected monomers were synthesized and incorporated into aegPNA oligomers at predetermined positions and their binding abilities with cDNA and RNA were investigated. A single incorporation of the modified PNA monomer into a 12-mer PNA sequence resulted in stronger binding with complementary RNA over cDNA. No significant changes in the CD signatures of the derived duplexes of modified PNA with complementary RNA were observed. (C) 2013 Elsevier Ltd. All rights reserved.

}, keywords = {Antisense therapeutics, Conformationally constrained PNA, Diagnostics, Peptide nucleic acid (PNA)}, issn = {0968-0896}, doi = {10.1016/j.bmc.2013.05.015}, author = {Banerjee, Anjan and Kumar, Vaijayanti A.} } @article {45703, title = {Critical role of select peptides in the loop region of G-rich PNA in the preferred G-quadruplex topology and stability}, journal = {Tetrahedron}, volume = {73}, year = {2017}, month = {MAR}, pages = {1534-1540}, type = {Article}, abstract = {

An uncharged PNA 15mer sequence formed unimolecular antiparallel G-quadruplex similar to that observed for DNA-TBA. Replacement of {\textquoteleft}tt{\textquoteright} loop regions by peptides which induce helices or turns were found to have unpresidented effect on the quadruplex topology and stability. This study opens up a completely new strategy of utilizing G-quadruplex formation to display the array of functional groups in the three dimensional space thus creating a possibility of getting closer to the dream of designed peptides with three dimensional structures as observed in catalytic protein folds. (C) 2017 Elsevier Ltd. All rights reserved.

}, keywords = {ESI-MS study, G-quadruplex, Peptide nucleic acid, topology}, issn = {0040-4020}, doi = {10.1016/j.tet.2017.01.055}, author = {Bose, Tanaya and Kumar, Vaijayanti A.} }