@article {44502,
	title = {Synthesis of key intermediate for (+)-tofacitinib through CoIII(salen)-catalyzed two stereocentered hydrolytic kinetic resolution of ({\^A}{\textpm})-methyl-3-(oxiran-2-yl)butanoate},
	journal = { Synthetic Communications},
	volume = {48},
	year = {2018},
	month = {MAR},
	pages = {1045-1051},
	type = {Journal Article},
	abstract = {An enantiopure piperidine, a key intermediate for the synthesis of (+)-tofacitinib, has been achieved in high optical purity (98\% ee) from readily available crotyl alcohol. The key steps involved is a CoIII(salen)-OAc-catalyzed two stereocentered hydrolytic kinetic resolution of ({\textpm})-methyl-3-(oxiran-2-yl)butanoate.},
	keywords = {enantioselective, Hydrolytic kinetic resolution, iodolactonization, γ-Butyralactone},
	issn = {397911},
	doi = {10.1080/00397911.2018.1434204},
	author = {Kamble, Rohit B.},
	editor = {Suryavanshi, Gurunath}
}
@article {47427,
	title = {Short enantioselective total synthesis of (+)-tofacitinib},
	journal = {Tetrahedron Letters},
	volume = {67},
	year = {2021},
	month = {MAR},
	pages = {152838},
	type = {Article},
	abstract = {<p>An enantioselective total synthesis of Tofacitinib (CP-690,550), a Janus tyrosine kinase (JAK3) specific inhibitor has been achieved from the readily available 4-piperidone. Proline catalysed hydroxylation is the key step for the synthesis of enantiopure 1-benzyl-4-methylpiperidin-3-ol. (C) 2021 Elsevier Ltd. All rights reserved.</p>},
	keywords = {aminohydroxylation, Hydrogenation, L-proline, piperidone},
	issn = {0040-4039},
	doi = {10.1016/j.tetlet.2021.152838},
	author = {Mane, Kishor D. and Kamble, Rohit B. and Suryavanshi, Gurunath}
}
