@article { ISI:000377612300008,
	title = {Synthesis of revised structure of klaivanolide (acetylmelodorinol)},
	journal = {Arkivoc},
	number = {2},
	year = {2016},
	month = {OCT},
	pages = {116-122},
	publisher = {ARKAT USA INC},
	address = {C/O ALAN R KATRITZKY, UNIV FLORIDA, DEPT CHEMISTRY, PO BOX 117200, GAINESVILLE, FL 32611 USA},
	abstract = {<p>Klaivanolide (acetylmelodorinol) is an anti-leishmanial/anti-trypanosomal agent isolated from Uvaria klaineana and the structure was originally assigned as a 7-membered lactone with extended conjugation and S-configuration at the lactone junction. Very recently, the structure of klaivanolide was revised as previously known compound acetylmelodorinol. Now, we have synthesized the revised structure in racemic form using a short route.</p>},
	keywords = {acetylmelodorinol, Klaivanolide, leishmaniasis, Natural product},
	issn = {1551-7004},
	doi = {10.3998/ark.5550190.p009.231},
	author = {Raut, Gajanan N. and Wagh, Sachin B. and Reddy, D. Srinivasa}
}
@article {48826,
	title = {Synthesis, biological evaluation and docking studies of silicon incorporated diarylpyrroles as MmpL3 inhibitors: an effective strategy towards development of potent anti-tubercular agents},
	journal = {European Journal of Medicinal Chemistry},
	volume = {259},
	year = {2023},
	month = {NOV },
	pages = {115633},
	type = {Article},
	abstract = {<p>
	Growing global demand for new molecules to treat tuberculosis has created an urgent need to develop novel strategies to combat the menace. BM212 related compounds were found to be potent anti-TB agents and they inhibit mycolic acid transporter, MmpL3, a known potent drug target from Mycobacterium tuberculosis. In order to enhance their inhibitory potency, several silicon analogues of diarylpyrroles related to BM212 were designed, synthesized, and evaluated for anti-tubercular activities. In Alamar blue assay, most of the silicon-incorporated compounds were found to be more potent than the parent compound (BM212), against Mycobacterium tuberculosis (MIC = 1.7 \&amp; mu;M, H37Rv). Docking results from the crystal structure of MmpL3 and silicon analogues as pharmacophore model also strongly correlate with the biological assays and suggest that the incorporation of silicon in the inhibitor scaffold could enhance their potency by stabilizing the hydrophobic residues at the binding pocket. The best docking hit, compound 12 showed an MIC of 0.1 \&amp; mu;M against H37Rv with an acceptable in vitro ADME profile and excellent selectivity index. Overall, the present study indicates that, the designed silicon analogues, especially compound 12 could be a good inhibitor for an intrinsically flexible drug-binding pocket of MmpL3 and has potential for further development as anti-tubercular agents.</p>
},
	keywords = {antibiotic, BM212, docking studies, MmpL3 inhibitor, Silicon analogue, tuberculosis},
	issn = {0223-5234},
	doi = {10.1016/j.ejmech.2023.115633},
	author = {Vasudevan, N. and Motiwala, Zenia and Ramesh, Remya and Wagh, Sachin B. and Shingare, Rahul D. and Katte, Revansiddha and Anand, Amitesh and Choudhary, Sushil and Kumar, Ajay and Gokhale, Rajesh S. and Kulkarni, Kiran A. and Reddy, D. Srinivasa}
}
